Last reviewed · How we verify
NCT03974399
BDNF Levels After Bacopa
NA trial testing Bacopa Monnieri in Memory in 44 participants. Completed in 1 June 2020.
1 April 2020
Quick facts
| Lead sponsor | Roskamp Institute Inc. |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 44 |
| Start date | 30 May 2019 |
| Primary completion | 1 April 2020 |
| Estimated completion | 1 June 2020 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Bacopa Monnieri — full drug profile →
Conditions studied
- Memory — all drugs for Memory →
Sponsor
Roskamp Institute Inc.
Who can join
Adults 60 to 78, any sex, with Memory. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Brain-derived neurotrophic factor (BDNF) is a well-known neurotrophic factor important for learning, memory, and synaptogenesis. Healthy activities such as exercise are believed to raise BDNF, while stress is associated with lower BDNF. What is not well understood is if there are certain supplements that may raise BDNF over time. Bacopa monnieri is well characterized nutraceutical. Animal and pre-clinical data support multiple beneficial mechanisms, including raising BDNF and increasing synaptogenesis. Additionally, small studies have shown Bacopa enhances cognition and improves mood. We would like to investigate if BDNF level changes in people after starting Bacopa.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
<i>Bacopa monnieri</i> supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderly subjects.
Keegan AP, Stough C, Paris D, Luis CA, et al · · 2023 · cited 4× · PMID 37032999
Verify or expand the search:
- PubMed search for NCT03974399
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Roskamp Institute Inc. trials
Trials by the same sponsor.
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- NCT05252949 — OEA for Targeting Lipid Metabolism in GWI · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03974399 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Roskamp Institute Inc.
- Last refreshed: 2 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03974399.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing