Impact of Metformin on Leptin Transport in Cerebrospinal Fluid of Obese Patients (LEPTOB)

NCT03974139 PHASE2 UNKNOWN

Obesity, a major health problem, is gradually transforming into a global epidemic. The current obesity treatment with long term efficacy is the bariatric surgery, however, the operative risk of this procedure is high and the post-operative iotrogeny may be important. Obesity is most often associated to the feeding behavior which depends on hypothalamic integration of peripheral signals such as leptin and glucose. High levels of circulating leptin are detected in obese patients. These elevated leptin levels fail to reduce appetite or increase energy expenditure. The mechanism underlying this non-integration of peripheral signals remains to be identified. The ratio of leptin levels in the cereprospinal fluid (CSF) and in the periphery is drastically decreased in obese patients when compared to lean individuals, therefore a defective transport of circulating leptin into the brain via the CSF is maybe linked to obesity.

Details

Lead sponsor	Lille Catholic University
Phase	PHASE2
Status	UNKNOWN
Enrolment	31
Start date	Fri Jul 03 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Sep 30 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Obesity Without Type 2 Diabetes, With BMI>30

Interventions

• Metformin Oral Tablet

Countries

France