NCT03970499: ELASTOGLI

Ultrasound Elastography and Ultrasentive Doppler for Surgery of Brain Tumors

Completed NA Last updated 5 December 2023

What this trial tests

NA trial testing brain tumor resection in Brain Tumor, Primary in 20 participants. Completed in 15 April 2023.

Timeline

15 April 2019

Primary endpoint
15 April 2023

15 April 2023

Quick facts

Lead sponsor	University Hospital, Tours
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	20
Start date	15 April 2019
Primary completion	15 April 2023
Estimated completion	15 April 2023
Sites	1 location across France

Drugs / interventions tested

• brain tumor resection

Conditions studied

• Brain Tumor, Primary — all drugs for Brain Tumor, Primary →

Sponsor

University Hospital, Tours

Who can join

18 and older, any sex, with Brain Tumor, Primary. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Surgery for brain gliomas is usually guided by different imaging techniques including neuronavigation MRI and intraoperative ultrasound that do not allow visualization of the low-density peri-lesional tumor infiltration present in gliomas and from which the tumor recurs.

Another important aspect in the management of glial tumors is the histological grade. The appearance of new vessels (called neo-angiogenesis) is one of the crucial steps in the life of these tumors, which signifies the transition to anaplasia.

This neoangiogenesis is diagnosed during the anatomopathological analysis of the operative specimen, and may be suspected on preoperative MRI on the so-called infusion sequences.

The objective of this project is to evaluate the potential of two ultrasound modalities - elastography and ultrasensitive Doppler - in helping the surgical management of brain tumors. Ultrasound elastography measures cerebral elasticity and thus indirectly the degree of tumor infiltration; while ultrasensitive Doppler measures intratumoral vascularization, and could therefore help in the diagnosis of tumor anaplasia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Multi-layered adaptive neoangiogenesis Intra-Operative quantification (MANIOQ).
   Lacoin G, Zemmoura I, Gennisson JL, Kouamé D, et al · · 2023 · cited 1× · PMID 37070356 · DOI 10.1177/0271678x231170504