NCT03969745 (TRF) is a NA clinical trial of Time restricted feeding in Metabolic Health, sponsored by University of Nottingham.

Who is sponsoring NCT03969745?

NCT03969745 is sponsored by University of Nottingham.

What drugs are being tested in NCT03969745?

Interventions in NCT03969745: Time restricted feeding, Caloric restriction.

What condition does NCT03969745 study?

NCT03969745 studies Metabolic Health.

Is NCT03969745 still recruiting?

NCT03969745 is currently completed. Last updated 9 September 2019.

Last reviewed 2019-09-09 · How we verify

NCT03969745: TRF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Two-weeks of Time Restricted Feeding on Basal and Postprandial Metabolism in Healthy Men

Completed NA Last updated 9 September 2019

What this trial tests

NA trial testing Time restricted feeding in Metabolic Health in 16 participants. Completed in 30 May 2019.

Timeline

26 June 2017

Primary endpoint
30 May 2019

30 May 2019

Quick facts

Lead sponsor	University of Nottingham
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	16
Start date	26 June 2017
Primary completion	30 May 2019
Estimated completion	30 May 2019
Sites	1 location across United Kingdom

Drugs / interventions tested

Time restricted feeding
Caloric restriction

Conditions studied

Metabolic Health — all drugs for Metabolic Health →

Sponsor

University of Nottingham

Who can join

Adults 18 to 35, male only, with Metabolic Health. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In the modern era, food access is widely available and it is not uncommon for the time between breakfast and a late night snack to exceed 14 hours. The investigators are interested in studying whether limiting this window to 8 hours will have any beneficial effects of human health as has been demonstrated in animal models. Eight men were asked to restrict their energy intake window to between 8 am and 4 pm for two weeks whilst maintaining their habitual diet (quantity and composition). Improvements in skeletal muscle and whole-body insulin sensitivity were observed but these were potentially confounded by an average weight loss of 1 kg. Therefore an additional control group was recruited to follow a daily caloric deficit of \~400 kilocalories without changing the timing of intake.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men.
Jones R, Pabla P, Mallinson J, Nixon A, et al · · 2020 · cited 93× · PMID 32729615 · DOI 10.1093/ajcn/nqaa192

Verify or expand the search:

Other trials of Time restricted feeding

Trials testing the same drug.

NCT05038137 — Time Restricted Eating on Cancer Risk · NA · completed
NCT05593939 — Slow Age: Interventions to Slow Aging in Humans · Phase 2 · completed
NCT05756868 — The Effect of Time-Restricted Feeding on Anthropometry, Biochemical Parameters, Diet Quality and Eating Behavior · NA · completed
NCT05717127 — Metabolic Impact of Intermittent Fasting in Early Type 2 Diabetes · NA · completed
NCT04988230 — Time Restricted Feeding on Nonalcoholic Fatty Liver Disease ( TREATY-FLD )：a 12-month Follow-up Study · NA · completed

Other recruiting trials for Metabolic Health

Currently open trials in the same condition.

NCT07489118 — Impact of Protein Source and Polyphenol Complexation in Protein Bars on Metabolic Health · NA · active not recruiting
NCT07481578 — Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of · NA · recruiting
NCT03670524 — Health, Environment and Action in Louisville (HEAL) Green Heart Louisville Project · NA · recruiting

Other University of Nottingham trials

Trials by the same sponsor.

NCT07518381 — Medication Understanding in MS · not yet recruiting
NCT07355556 — Technology Supported Improvement, Management and Prevention of Accidental Falls in Hospitals · not yet recruiting
NCT07506408 — Randomised Study of Web-Based Auditory Training With Varying Perceptual and Cognitive Demands on Training Gains and Gene · NA · recruiting
NCT07237529 — What is the Feasibility of Narrative Exposure Therapy (NET) for People Experiencing Psychosis? · NA · not yet recruiting
NCT07237997 — Protein Supplementation During Dialysis (PROSED) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03969745 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Nottingham
Last refreshed: 9 September 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03969745.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing