NCT03967106 (MSIPC-2) is a NA clinical trial of Ischaemic Preconditioning in Multiple Sclerosis, sponsored by Sheffield Teaching Hospitals NHS Foundation Trust.

Who is sponsoring NCT03967106?

NCT03967106 is sponsored by Sheffield Teaching Hospitals NHS Foundation Trust.

What drugs are being tested in NCT03967106?

Interventions in NCT03967106: Ischaemic Preconditioning, Sham.

What condition does NCT03967106 study?

NCT03967106 studies Multiple Sclerosis.

Is NCT03967106 still recruiting?

NCT03967106 is currently completed. Last updated 5 January 2024.

Last reviewed 2024-01-05 · How we verify

NCT03967106: MSIPC-2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

RIPC on Activity, Fatigue and Gait in MS

Completed NA Last updated 5 January 2024

What this trial tests

NA trial testing Ischaemic Preconditioning in Multiple Sclerosis in 92 participants. Completed in 31 March 2023.

Timeline

19 August 2019

Primary endpoint
31 March 2023

31 March 2023

Quick facts

Lead sponsor	Sheffield Teaching Hospitals NHS Foundation Trust
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	supportive care
Enrollment	92
Start date	19 August 2019
Primary completion	31 March 2023
Estimated completion	31 March 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

Ischaemic Preconditioning
Sham

Conditions studied

Multiple Sclerosis — all drugs for Multiple Sclerosis →

Sponsor

Sheffield Teaching Hospitals NHS Foundation Trust

Who can join

18 and older, any sex, with Multiple Sclerosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates whether Remote Ischaemic Preconditioning (RIPC) can improve activity, gait and fatigue in people with Multiple Sclerosis. Half the participants will receive RIPC, the other half will receive a sham treatment.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Mobility recorded by wearable devices and gold standards: the Mobilise-D procedure for data standardization.
Palmerini L, Reggi L, Bonci T, Del Din S, et al · · 2023 · cited 25× · PMID 36658136 · DOI 10.1038/s41597-023-01930-9
Remote ischaemic conditioning for neurological disorders-a systematic review and narrative synthesis.
Alhashimi A, Kamarova M, Baig SS, Nair KPS, et al · · 2024 · cited 5× · PMID 39702489 · DOI 10.1186/s13643-024-02725-8
Variability of Multiple Sclerosis Walking Scale and Multiple Sclerosis Impact Scale Scores in People Without Multiple Sclerosis.
Binshalan T, Buckley E, Nair S, Mcneill A. · · 2024 · cited 1× · PMID 38322083 · DOI 10.7759/cureus.51811
Abstracts of the BSPRM Annual Scientific Conference 2024
· 2025
Remote Ischaemic Conditioning for Neurological Disorders – A Systematic Review and Narrative Synthesis
Alhashimi A, Kamarova M, B S, Nair KS, et al · · 2024 · DOI 10.21203/rs.3.rs-3974093/v1

Verify or expand the search:

Other trials of Ischaemic Preconditioning

Trials testing the same drug.

NCT05954715 — Ischaemic Preconditioning and Upper Body Exercise Performance in Persons With Spinal Cord Injury · NA · unknown

Other recruiting trials for Multiple Sclerosis

Currently open trials in the same condition.

NCT07507084 — The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Wal · NA · recruiting
NCT07524231 — Evaluation of the Effects of Laughter Yoga · NA · recruiting
NCT07489794 — URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS · recruiting
NCT07236684 — Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other Sheffield Teaching Hospitals NHS Foundation Trust trials

Trials by the same sponsor.

NCT07407712 — Better Outcomes Through Optimal Sleep in Surgical Training · NA · recruiting
NCT07172555 — Virtual Dietetic Interventions in Patients With Coeliac · NA · recruiting
NCT06310993 — Exercise to Boost Immunity in Advanced Cancer · NA · not yet recruiting
NCT06905405 — The Use of Advanced Imaging in HFpEF · recruiting
NCT06633627 — Neurological Responses in Patients with Dentine Hypersensitivity · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03967106 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Sheffield Teaching Hospitals NHS Foundation Trust
Last refreshed: 5 January 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03967106.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing