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NCT03966313: HemostVAD
Perioperative Modification of Hemostasis During Ventricular Assist Device Implantation
trial testing ventricular assist device implantation in End-stage Heart Failure in 26 participants. Terminated before completion.
13 April 2024
Quick facts
| Lead sponsor | University Hospital, Strasbourg, France |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 26 |
| Start date | 21 June 2019 |
| Primary completion | 13 April 2024 |
| Estimated completion | 13 April 2024 |
| Sites | 1 location across France |
Drugs / interventions tested
- ventricular assist device implantation
Conditions studied
- End-stage Heart Failure — all drugs for End-stage Heart Failure →
Sponsor
University Hospital, Strasbourg, France
Who can join
18 and older, any sex, with End-stage Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Implanting a ventricular assist device (VAD) is a promising therapy for end-stage cardiac failure. However, the implantation of these devices is associated with a high risk of severe hemorrhages and massive blood product transfusion in the first 48 hours following the implantation. The primary purpose of this study is to assess the functionality of the von Willebrand Factor (vWF) which is essential for hemostasis. The hypothesis is that the high shear stress generated by these VAD expose ADAMTS13 cleaving site on the vWF. This result in a loss of high molecular weight vWF and an acquired von Willebrand syndrome. The secondary purpose of the protocol is to assess platelet function after the implantation of VAD. Indeed, platelet function might be affected shortly after the implantation of the device.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03966313
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other recruiting trials for End-stage Heart Failure
Currently open trials in the same condition.
- NCT07382284 — Long-Term Survival After LVAD Implantation in End-Stage Heart Failure · recruiting
- NCT05353816 — Corheart 6 Left Ventricular Assist System Prospective, Multicenter, Single-arm Clinical Evaluation Trial · NA · active not recruiting
Other University Hospital, Strasbourg, France trials
Trials by the same sponsor.
- NCT07418554 — Sleep Disturbances in Children and Adolescents With Post-traumatic Stress Disorder (PTSD): a Randomized Double-blind Pla · Phase 3 · not yet recruiting
- NCT07108582 — Reducing Chronic Pain After Lung Surgery: A Trial of Limiting NSAIDs During Recovery · Phase 3 · not yet recruiting
- NCT07302646 — Optimizing Reduced-Flow, Low-Volume Contrast Protocols for Cerebral Angiography in Unruptured Aneurysms · NA · not yet recruiting
- NCT07273968 — Clinical Study Evaluating the Effect of Virtual Reality on Reducing Patients' Anxiety During Wisdom Teeth Extraction · NA · not yet recruiting
- NCT07214103 — Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulop · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03966313 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Strasbourg, France
- Last refreshed: 25 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03966313.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing