Who is sponsoring NCT03964129?

NCT03964129 is sponsored by Brooke Army Medical Center.

What drugs are being tested in NCT03964129?

Interventions in NCT03964129: Avance Nerve Graft with Autologous BMAC.

What condition does NCT03964129 study?

NCT03964129 studies Peripheral Nerve Injury Upper Limb.

Is NCT03964129 still recruiting?

NCT03964129 is currently status unknown. Last updated 16 July 2020.

Last reviewed 2020-07-16 · How we verify

NCT03964129

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

BMAC Nerve Allograft Study

Status unknown NA Last updated 16 July 2020

What this trial tests

NA trial testing Avance Nerve Graft with Autologous BMAC in Peripheral Nerve Injury Upper Limb in 15 participants. Status unknown.

Timeline

22 August 2017

Primary endpoint
30 November 2020

1 June 2021

Quick facts

Lead sponsor	Brooke Army Medical Center
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	15
Start date	22 August 2017
Primary completion	30 November 2020
Estimated completion	1 June 2021
Sites	3 locations across United States

Drugs / interventions tested

Avance Nerve Graft with Autologous BMAC

Conditions studied

Peripheral Nerve Injury Upper Limb — all drugs for Peripheral Nerve Injury Upper Limb →

Sponsor

Brooke Army Medical Center

Who can join

Adults 18 to 74, any sex, with Peripheral Nerve Injury Upper Limb. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a prospective, multi-center, proof of principle, phase I human safety study evaluating the sequential treatments of the Avance Nerve Graft, a commercially available decellularized processed peripheral nerve allograft, with autologous Bone Marrow Aspirate Concentrate (BMAC), a source of stem cells, for the repair of peripheral nerve injuries up to 7 cm in length. The purpose of this study is to establish a knowledge product, evaluating the safety profile of the Avance Nerve Graft, followed by the application of BMAC to support further investment into the promising area of using stem cells in conjunction with scaffolds.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit.
Carvalho CR, Oliveira JM, Reis RL. · · 2019 · cited 201× · PMID 31824934 · DOI 10.3389/fbioe.2019.00337
Polymeric Materials, Advances and Applications in Tissue Engineering: A Review.
Socci MC, Rodríguez G, Oliva E, Fushimi S, et al · · 2023 · cited 38× · PMID 36829712 · DOI 10.3390/bioengineering10020218
Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb.
Thomson SE, Ng NY, Riehle MO, Kingham PJ, et al · · 2022 · cited 26× · PMID 36477774 · DOI 10.1002/14651858.cd012574.pub2
Stem Cells and Tissue Engineering-Based Therapeutic Interventions: Promising Strategies to Improve Peripheral Nerve Regeneration.
de Assis ACC, Reis ALS, Nunes LV, Ferreira LFR, et al · · 2023 · cited 14× · PMID 35107689 · DOI 10.1007/s10571-022-01199-3
Influencing factors and repair advancements in rodent models of peripheral nerve regeneration.
Olsen TC, LaGuardia JS, Chen DR, Lebens RS, et al · · 2024 · cited 3× · PMID 39469920 · DOI 10.1080/17460751.2024.2405318
Mesenchymal stem cells' "garbage bags" at work: Treating radial nerve injury with mesenchymal stem cell-derived exosomes.
Mushtaq M, Zineldeen DH, Mateen MA, Haider KH. · · 2024 · cited 2× · PMID 38817330 · DOI 10.4252/wjsc.v16.i5.467
Peripheral nerve repair: innovations and future directions.
Aldali F, Tang L, Yang Y, Huang Y, et al · · 2026 · PMID 41634808 · DOI 10.1186/s12967-025-07567-z

Verify or expand the search:

Other recruiting trials for Peripheral Nerve Injury Upper Limb

Currently open trials in the same condition.

NCT06616025 — This Study Will Evaluate the Effectiveness of NTX-001, a Surgical Nerve Repair Product When Used in People With Upper Ex · Phase 3 · recruiting

Other Brooke Army Medical Center trials

Trials by the same sponsor.

NCT06940986 — The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System · NA · not yet recruiting
NCT06699901 — Antibiotic Concentrations After MassivE Transfusion Study · recruiting
NCT06602375 — The Effect of Manual Physical Therapy and Exercise in Addition to Routine Dental Care in Individuals With Temporomandibu · NA · recruiting
NCT06560190 — Orthopaedic Manual Physical Therapy as Part of the Postpartum Care Continuum · NA · recruiting
NCT06369701 — Effects Compressive Tissue Flossing on Lateral Elbow Tendinopathy in US Service Members · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03964129 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brooke Army Medical Center
Last refreshed: 16 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03964129.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing