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NCT03959839: DSETAMIS2018
Endoscopic Submucosal Dissection vs Local Laparoscopic Surgical Resection (TAMIS/TEO) in Early Rectal Neoplasias
NA trial testing ESD in Rectal Neoplasms in 70 participants. Completed in 20 December 2024.
20 December 2024
Quick facts
| Lead sponsor | Dr. Alberto Herreros de Tejada Echanojáuregui |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 70 |
| Start date | 1 April 2019 |
| Primary completion | 20 December 2024 |
| Estimated completion | 20 December 2024 |
| Sites | 3 locations across Spain |
Drugs / interventions tested
- ESD
- TAMIS
- TEO
Conditions studied
- Rectal Neoplasms — all drugs for Rectal Neoplasms →
Sponsor
Dr. Alberto Herreros de Tejada Echanojáuregui
Who can join
18 and older, any sex, with Rectal Neoplasms. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A multicenter non-inferiority randomized clinical trial to compare Endoscopic treatment (ESD) and Minimally Invasive Laparoscopic Local Surgical Treatment (TAMIS or TEO) for early rectal neoplastic lesions (adenoma \& T1CRC) Primary aim: To compare the long-term local recurrence rate (12 months after the procedure) Secondary aims: Compare en-bloq resection rate, R0 resection, time per procedure, short-term recurrence rate, safety (rate of complications), morbidity and cost-effectiveness analyses.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Randomized Trial of Endoscopic Submucosal Dissection vs Transanal Minimally Invasive Surgery in Early Rectal Neoplasms: DSETAMIS-2018 Study.
de Frutos Rosa D, Alonso Sebastián I, Barquero Declara D, Badia Closa J, et al · · 2026 · cited 2× · PMID 40749854 · DOI 10.1053/j.gastro.2025.07.029
Verify or expand the search:
- PubMed search for NCT03959839
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of ESD
Trials testing the same drug.
- NCT07401303 — Full-time RDI for ESD: Impact on Major Adverse Events and Procedure Time · NA · not yet recruiting
- NCT07041229 — Comparison of Methods for Removing Large Benign Broad-based Epithelial Neoplasms of the Colon: ESD and EMR. · NA · enrolling by invitation
- NCT05983419 — Complete Resection of Barrett's Esophagus Harboring Neoplasia With Endoscopic Submucosal Dissection. · NA · unknown
- NCT05276791 — EMR Versus ESD for Barrett's Neoplasia · NA · not yet recruiting
- NCT05208775 — A Comparative Study of Endoscopic Submucosal Dissection and Photodynamic Therapy for Early Esophageal Cancer · NA · unknown
Other recruiting trials for Rectal Neoplasms
Currently open trials in the same condition.
- NCT07522294 — Optimization and Standardization of Single-Port Robotic Transanal Minimally Invasive Surgery for Rectal Tumor Excision · NA · active not recruiting
- NCT07154173 — Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer · recruiting
- NCT06442215 — Selection of Surgical Technique in Rectal Cancer · recruiting
- NCT06017583 — Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal Cancer · Phase 3 · recruiting
- NCT05943444 — Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer · NA · recruiting
Other Dr. Alberto Herreros de Tejada Echanojáuregui trials
Trials by the same sponsor.
- NCT03436004 — Evaluation of Colonoscopy With a Specific Device for the Detection of Adenomas · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03959839 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dr. Alberto Herreros de Tejada Echanojáuregui
- Last refreshed: 3 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03959839.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing