Last reviewed · How we verify
NCT03958903
Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation
NA trial testing Amygdala recording and stimulation using Neuropace RNS in Fear in 23 participants. Completed in 13 March 2020.
13 March 2020
Quick facts
| Lead sponsor | Stanford University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 23 |
| Start date | 24 April 2019 |
| Primary completion | 13 March 2020 |
| Estimated completion | 13 March 2020 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Amygdala recording and stimulation using Neuropace RNS
- Behavioral tasks
Conditions studied
- Fear — all drugs for Fear →
- PTSD — all drugs for PTSD →
- Panic Disorder — all drugs for Panic Disorder →
Sponsor
Stanford University
Who can join
Adults 18 to 65, any sex, with Fear or PTSD. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to specifically examine the in vivo electrophysiology and effects of direct stimulation of the human amygdala during conditioned and evoked fear. Investigators will also examine amygdala electrophysiology and the effects of stimulation during tasks to examine the effects of reward on fear memory. This study will recruit subjects with a history of temporal lobe epilepsy (TLE) who have undergone neurosurgical implantation with FDA-approved, NeuroPace RNS devices for treatment of seizures. These patients provide a unique cohort with (Responsive Neurostimulation) RNS devices capable of both recording and stimulating the amygdala during performance of fear-based, behavioral tasks.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03958903
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
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Other Stanford University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03958903 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Stanford University
- Last refreshed: 26 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03958903.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing