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Effect of Valproate Versus Levetiracetam Monotherapy on Reproductive Functions in Epileptic Males
Background: Different antiepileptic drugs are responsible for reproductive dysfunction in male epileptic patients. The aim of this study is to evaluate the effect of valproate versus levetiracetam as a monotherapy on males' sex hormones and sperm parameters in newly diagnosed epilepsy. Methods: This comparative study included 50 newly diagnosed epileptic male participants from outpatient clinic of Neurology department of Zagazig University Hospitals. All participants were subjected to complete general and neurological examination, Doppler ultrasonography of the testis, pre and post treatment serum sex hormone assay and semen analysis. Post- treatment re- evaluation check point was determined if eight weeks have passed after the last seizures. This study included two groups, group I: 25 participants, were treated by valproate (VPA) as a monotherapy till became seizure free at the last 8-weeks before post treatment check-point, with ages ranged from 18-43 years. Group II: 25 participants were treated by levetiracetam (LEV) with the same regimens of valproate as a monotherapy, with ages ranged from 20-45 years.
Details
| Lead sponsor | Zagazig University |
|---|---|
| Status | COMPLETED |
| Enrolment | 50 |
| Start date | Wed Jun 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Jun 30 2017 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Epilepsy
Interventions
- Effect of valporate on Reproductive Functions in Newly Diagnosed Epileptic Males
- Effect of levetiracetam on epileptic males reproductive function