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NCT03952000
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
NA trial testing Exercise in Diabetes Mellitus, Type 2 in 30 participants. Completed in 1 September 2019.
1 September 2019
Quick facts
| Lead sponsor | Loughborough University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 30 |
| Start date | 3 January 2019 |
| Primary completion | 1 September 2019 |
| Estimated completion | 1 September 2019 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Exercise
Conditions studied
- Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
- Endothelial Dysfunction — all drugs for Endothelial Dysfunction →
- Insulin Resistance — all drugs for Insulin Resistance →
Sponsor
Loughborough University
Who can join
Adults 18 to 60, male only, with Diabetes Mellitus, Type 2 or Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men. Participants will complete two, 2-day trials in a random, crossover design separated by at least a week. On day 1, participants will either rest or complete a 60 minute walk at 60% maximal oxygen uptake. On day 2, participants will arrive at 08:00 having fasted overnight and a baseline venous blood sample and endothelial function measurement will be taken. Participants will consume a high-fat breakfast and lunch and 12 subsequent venous blood samples will be taken throughout the day at standardised intervals to measure a variety of coronary heart disease risk markers. A second endothelial function measurement will be completed 2 hours after the breakfast. Blood pressure will be measured every hour. It is expected that the South Asian participants will have impaired metabolism and endothelial function compared to their European counterparts but the bout of exercise performed on day 1 will mitigate these responses.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans.
Roberts MJ, Thackray AE, Wadley AJ, Alotaibi TF, et al · · 2023 · cited 5× · PMID 36729923 · DOI 10.1249/mss.0000000000003098
Verify or expand the search:
- PubMed search for NCT03952000
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Loughborough University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03952000 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Loughborough University
- Last refreshed: 29 January 2020
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