NCT03950544 is a EARLY_PHASE1 clinical trial of Fosfomycin in Antibiotic Resistant Infection, sponsored by Shanghai 10th People's Hospital.

Who is sponsoring NCT03950544?

NCT03950544 is sponsored by Shanghai 10th People's Hospital.

What drugs are being tested in NCT03950544?

Interventions in NCT03950544: Fosfomycin, Tigecycline, Polymyxin B.

What condition does NCT03950544 study?

NCT03950544 studies Antibiotic Resistant Infection.

Is NCT03950544 still recruiting?

NCT03950544 is currently status unknown. Last updated 15 May 2019.

Last reviewed 2019-05-15 · How we verify

NCT03950544

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae

Status unknown EARLY_PHASE1 Last updated 15 May 2019

What this trial tests

EARLY_PHASE1 trial testing Fosfomycin in Antibiotic Resistant Infection in 80 participants. Status unknown.

Timeline

1 January 2019

Primary endpoint
31 August 2020

31 December 2020

Quick facts

Lead sponsor	Shanghai 10th People's Hospital
Phase	EARLY_PHASE1
Status	Status unknown
Study type	INTERVENTIONAL
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	80
Start date	1 January 2019
Primary completion	31 August 2020
Estimated completion	31 December 2020
Sites	1 location across China

Drugs / interventions tested

Fosfomycin (FOSFOMYCIN) — full drug profile →
Tigecycline (TIGECYCLINE) — full drug profile →
Polymyxin B (POLYMYXIN B) — full drug profile →

Conditions studied

Antibiotic Resistant Infection — all drugs for Antibiotic Resistant Infection →

Sponsor

Shanghai 10th People's Hospital

Who can join

Adults 18 to 80, any sex, with Antibiotic Resistant Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The infection of carbapenem resistant klebsiella pneumoniae (CRKP) is increasingly serious.Based on the early experimental basis and relevant research background,this study intends to separate and purify the CRKP from the bronchoalveolar lavage fluid (BALF) of the clinical patients.Designed by checkerboard assay and time-kill assay(TKA)，this study can explore the best combination therapy based on carbapenems.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Polymyxins: recent advances and challenges.
Yang S, Wang H, Zhao D, Zhang S, et al · · 2024 · cited 20× · PMID 38974043 · DOI 10.3389/fphar.2024.1424765
The Genomic Characterization of KPC-Producing <i>Klebsiella pneumoniae</i> from the ICU of a Teaching Hospital in Shanghai, China.
Du Y, Mu S, Liu Y, Yuan Y, et al · · 2022 · cited 3× · PMID 35046672 · DOI 10.2147/idr.s343673

Verify or expand the search:

Other trials of Fosfomycin

Trials testing the same drug.

NCT05260554 — Effect of Cranberry Extract on the Urinary System · completed
NCT05254808 — EXtended Use of FOsfomycin for the Treatment of CYstitis in Primary Care · Phase 3 · terminated
NCT06814899 — Use of Fosfomycin in the Treatment of Bacterial Infections · recruiting
NCT03228108 — Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy. · Phase 4 · completed
NCT05211011 — Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection · Phase 4 · unknown

Other recruiting trials for Antibiotic Resistant Infection

Currently open trials in the same condition.

NCT06607887 — The Role of Postoperative Antibiotics in Laparoscopic Cholecystectomy · Phase 4 · recruiting
NCT05224401 — Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs · Phase 3 · recruiting
NCT05502380 — Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery · Phase 3 · recruiting
NCT05871476 — Interventions to Decrease CRE Colonization and Transmission Between Hospitals, Households, Communities and Domesticated · NA · recruiting
NCT05561504 — Helicobacter Pylori Local Prevalence and Antibiotic Resistance · recruiting

Other Shanghai 10th People's Hospital trials

Trials by the same sponsor.

NCT07528040 — An Observational, Multicenter Study to Evaluate the Effectiveness of Guselkumab for the Treatment of Participants With C · not yet recruiting
NCT07370441 — Amino Acid (15) Peritoneal Dialysis Solution for Nutritional Improvement in Peritoneal Dialysis Patients · Phase 4 · not yet recruiting
NCT07328100 — Efficacy and Safety of Coenzyme I for Injection on Vascular Aging. · NA · not yet recruiting
NCT06783296 — Efficacy and Safety of Renal Denervation on Isolated Diastolic Hypertension · NA · not yet recruiting
NCT07204496 — A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03950544 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shanghai 10th People's Hospital
Last refreshed: 15 May 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03950544.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing