Last reviewed · How we verify
NCT03949738
Cerebrovascular Hemodynamics in Patients With ARDS.
trial testing Near-infrared spectroscopy-based assessement of cerebral autoregulation. in ARDS in 66 participants. Completed in 30 November 2020.
30 November 2019
Quick facts
| Lead sponsor | Universitätsklinikum Hamburg-Eppendorf |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 66 |
| Start date | 1 December 2018 |
| Primary completion | 30 November 2019 |
| Estimated completion | 30 November 2020 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Near-infrared spectroscopy-based assessement of cerebral autoregulation.
Conditions studied
- ARDS — all drugs for ARDS →
Sponsor
Universitätsklinikum Hamburg-Eppendorf — full company profile →
Who can join
18 and older, any sex, with ARDS. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The acute respiratory distress syndrome (ARDS) is a life-threatening disease with functional impairment of the lung. It is characterized by an excessive inflammatory response of lung tissue, capillaries, and blood vessels and is associated with high mortality. Patients who survive the acute phase of this critical disease often suffer from long-term physical, psychological, and mental sequelae, as well as persistent cognitive deficits. In healthy individuals, autoregulatory mechanisms of the intracranial blood vessels keep blood supply to the brain independent of fluctuations in systemic blood pressure. In the case of a serious illness, these mechanisms of autoregulation may be impaired, which may favor cerebral hypoperfusion. Impairment of cerebrovascular hemodynamics can lead to neuronal damage in short and long term. The aim of this project is to investigate cerebrovascular autoregulation in adult patients with ARDS and to evaluate the cognitive outcome at 3, 6 and 12 months after discharge from the intensive care unit.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study.
Kahl U, Yu Y, Nierhaus A, Frings D, et al · · 2021 · cited 7× · PMID 33725209 · DOI 10.1186/s13613-021-00831-7
Verify or expand the search:
- PubMed search for NCT03949738
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for ARDS
Currently open trials in the same condition.
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- NCT07370610 — Electrical Impedance Tomography-Based Dynamic Ventilation-Perfusion Functional Phenotype Trajectory in Acute Respiratory · active not recruiting
- NCT06647784 — Lateral Positioning and Prone Positioning in ARDS Patients · NA · recruiting
Other Universitätsklinikum Hamburg-Eppendorf trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03949738 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitätsklinikum Hamburg-Eppendorf
- Last refreshed: 26 October 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03949738.
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