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NCT03949361: GLACIER
Glucocorticoid Long-term Administration: Effect on Cold Induced Energy Expenditure and Resting Metabolic Rate
trial testing Indirect calorimetry in Thermoregulation Impairment in 7 participants. Completed in 1 December 2021.
1 December 2021
Quick facts
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 7 |
| Start date | 1 June 2019 |
| Primary completion | 1 December 2021 |
| Estimated completion | 1 December 2021 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Indirect calorimetry
- Skin Temperature
- Dual energy X-ray Absorptiometry (DXA)
- Blood Sampling — full drug profile →
- FDG-PET — full drug profile →
- Capillary glucose
- Biopsy of supraclavicular adipose tissue (optional)
Conditions studied
- Thermoregulation Impairment — all drugs for Thermoregulation Impairment →
Sponsor
University Hospital, Basel, Switzerland
Who can join
Adults 18 to 75, any sex, with Thermoregulation Impairment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to investigate whether treatment with glucocorticoids leads to a change in heat production of the human body at mild cold conditions.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men.
Maushart CI, Sun W, Othman A, Ghosh A, et al · · 2023 · cited 10× · PMID 37659283 · DOI 10.1016/j.ebiom.2023.104771
Verify or expand the search:
- PubMed search for NCT03949361
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Basel, Switzerland trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03949361 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
- Last refreshed: 25 January 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03949361.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing