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NCT03946150
PaO2/FiO2*PEEP (P/FP) Ratio and Mortality in Acute Respiratory Distress Syndrome.
trial testing P/FP Ratio in Adult Respiratory Distress Syndrome in 4,361 participants. Completed in 3 March 2020.
5 May 2019
Quick facts
| Lead sponsor | National University Health System, Singapore |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 4,361 |
| Start date | 1 June 2017 |
| Primary completion | 5 May 2019 |
| Estimated completion | 3 March 2020 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- P/FP Ratio
Conditions studied
- Adult Respiratory Distress Syndrome — all drugs for Adult Respiratory Distress Syndrome →
Sponsor
National University Health System, Singapore
Who can join
Adults 18 to 100, any sex, with Adult Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The PaO2/FiO2 (P/F) ratio is same for all the Positive End Expiratory Pressure (PEEP) ≥ to 5. This P/F ratio misleads the severity of disease without the knowledge of set PEEP. The Oxygenation status is actually worse when the patient is using high PEEP. P/F Ratio doesn't include PEEP in the calculation.The P/F ratio doesn't show the severity of the disease appropriate for the set PEEP. PaO2/(FiO2 X PEEP) P/FP Ratio is a new Formula which addresses this gap to appropriately calculate the severity of the disease by including PEEP in the formula. This formula is used to predict mortality for different severities of ARDS.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
P/FP ratio: incorporation of PEEP into the PaO<sub>2</sub>/FiO<sub>2</sub> ratio for prognostication and classification of acute respiratory distress syndrome.
Palanidurai S, Phua J, Chan YH, Mukhopadhyay A. · · 2021 · cited 41× · PMID 34370116 · DOI 10.1186/s13613-021-00908-3
Verify or expand the search:
- PubMed search for NCT03946150
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03946150 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National University Health System, Singapore
- Last refreshed: 26 March 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03946150.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing