NCT03943966 (iThrombus) is a NA clinical trial of 18F-GP1 PET CT in Thrombosis, sponsored by University of Edinburgh.

Who is sponsoring NCT03943966?

NCT03943966 is sponsored by University of Edinburgh.

What drugs are being tested in NCT03943966?

Interventions in NCT03943966: 18F-GP1 PET CT.

What condition does NCT03943966 study?

NCT03943966 studies Thrombosis, Atherothrombosis, Myocardial Infarction, STEMI, NSTEMI - Non-ST Segment Elevation MI, DVT, Pulmonary Embolism, Stroke, Transient Ischemic Attack, Prosthetic Valve Thrombosis, PET.

Is NCT03943966 still recruiting?

NCT03943966 is currently completed. Last updated 14 October 2021.

Last reviewed 2021-10-14 · How we verify

NCT03943966: iThrombus

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer

Completed NA Last updated 14 October 2021

What this trial tests

NA trial testing 18F-GP1 PET CT in Thrombosis in 73 participants. Completed in 13 October 2021.

Timeline

11 November 2019

Primary endpoint
2 July 2021

13 October 2021

Quick facts

Lead sponsor	University of Edinburgh
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	73
Start date	11 November 2019
Primary completion	2 July 2021
Estimated completion	13 October 2021
Sites	1 location across United Kingdom

Drugs / interventions tested

18F-GP1 PET CT

Conditions studied

Thrombosis — all drugs for Thrombosis →
Atherothrombosis — all drugs for Atherothrombosis →
Myocardial Infarction — all drugs for Myocardial Infarction →
STEMI — all drugs for STEMI →

Sponsor

University of Edinburgh

Who can join

40 and older, any sex, with Thrombosis or Atherothrombosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To date, the investigators have successfully employed a radiotracer (18F-sodium fluoride) as a marker of necrotic inflammation in human atherosclerosis. The investigators aim to further the mechanistic understanding of atherothrombosis by studying the activation of glycoprotein IIb/IIIa receptors in cardiovascular thrombus using the novel platelet radiotracer (18F-GP1). Binding of 18F-GP1 to activated platelets in venous and arterial thrombi has already been demonstrated in pre-clinical studies and a phase 1 trial in man. If successful, this study would define the role of the glycoprotein IIb/IIIa receptor within in vivo thrombosis across a range of cardiovascular diseases.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Noninvasive In Vivo Coronary Artery Thrombus Imaging.
Tzolos E, Bing R, Andrews J, MacAskill MG, et al · · 2023 · cited 23× · PMID 36526577 · DOI 10.1016/j.jcmg.2022.10.002
Latest Advances in Multimodality Imaging of Aortic Stenosis.
Tzolos E, Kwiecinski J, Berman D, Slomka P, et al · · 2022 · cited 18× · PMID 34887339 · DOI 10.2967/jnumed.121.262304
Noninvasive In Vivo Thrombus Imaging in Patients With Ischemic Stroke or Transient Ischemic Attack-Brief Report.
Whittington B, Tzolos E, Bing R, Andrews J, et al · · 2023 · cited 4× · PMID 37439259 · DOI 10.1161/atvbaha.122.318204
Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease.
Whittington B, Tzolos E, Joshi S, Bing R, et al · · 2024 · PMID 39500930 · DOI 10.1038/s41598-024-77151-w

Verify or expand the search:

Other recruiting trials for Thrombosis

Currently open trials in the same condition.

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NCT07358416 — Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery. · active not recruiting
NCT06370273 — Thromboprophylaxis in Lower Limb Immobilisation · Phase 3 · recruiting

Other University of Edinburgh trials

Trials by the same sponsor.

NCT07341126 — Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal · not yet recruiting
NCT07523997 — Imaging of Endometriosis With Total-body PET-CT (PET-Endo) · not yet recruiting
NCT07430540 — Optimising Colorectal Cancer Patient Pathways · NA · not yet recruiting
NCT07430527 — Secondary Care Colorectal Cancer Pathway Review · not yet recruiting
NCT07436026 — Latin America Network for Primary Palliative Care · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03943966 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Edinburgh
Last refreshed: 14 October 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03943966.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing