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NCT03940495
Serum Kisspeptin: a Predictive Marker of Miscarriage or Not?
trial in Miscarriage in 182 participants. Completed in 1 August 2020.
31 December 2019
Quick facts
| Lead sponsor | ShangHai Ji Ai Genetics & IVF Institute |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 182 |
| Start date | 1 May 2019 |
| Primary completion | 31 December 2019 |
| Estimated completion | 1 August 2020 |
| Sites | 1 location across China |
Conditions studied
- Miscarriage — all drugs for Miscarriage →
Sponsor
ShangHai Ji Ai Genetics & IVF Institute
Who can join
Eligibility, female only, with Miscarriage. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective observational study. Eligible women undergo ART treatment in our centre will be recruited for the study and each woman will only be included in the study once. Informed written consent will be obtained. Blood serum for hCG level is performed 14 days after the embryo transfer i.e. week 4. If the serum hCG level is \>10IU/L, the women are considered pregnant and blood will be saved and checked for kisspeptin level, Another blood test is repeated 1 week later i.e. week 5. A transvaginal ultrasound and blood test will be performed 1 week later i.e. week 6 to confirm the fetal viability and the number of gestational sacs and locate the pregnancy. Blood for hCG and kisspeptin levels are checked at weeks, 4, 5 and 6. Ultrasound will be performed at gestational 8 weeks and 11 weeks. They will be referred for antenatal care when the pregnancy is confirmed on-going at 11 weeks. The purpose is to determine whether serum kisspeptin level in women who conceive in IVF is associated with an increased risk in first trimester miscarriage and compare with serum hCG level in the prediction of the first trimester miscarriage.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction.
Sliwowska JH, Woods NE, Alzahrani AR, Paspali E, et al · · 2024 · cited 9× · PMID 38599822 · DOI 10.1111/1753-0407.13541 -
A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.
Li H, Zhang W, Sun X. · · 2024 · cited 1× · PMID 37935913 · DOI 10.1007/s10815-023-02974-x
Verify or expand the search:
- PubMed search for NCT03940495
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Miscarriage
Currently open trials in the same condition.
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- NCT06576622 — PERIodontal Disease, Microbiota and Miscarriage · recruiting
- NCT06862089 — A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV · recruiting
- NCT06452719 — Letrozole and Misoprostol for Early Pregnancy Loss Management · Phase 2 · recruiting
- NCT05725512 — Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages · Phase 4 · recruiting
Other ShangHai Ji Ai Genetics & IVF Institute trials
Trials by the same sponsor.
- NCT05326087 — Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT · Phase 3 · not yet recruiting
- NCT06561451 — Live Birth Rate Between ICSI and AOA and ICSI Alone in Patients With Severe Teratospermia · NA · recruiting
- NCT05739019 — The Impact of Past Coronavirus Disease 19 (COVID-19) Infection on the Live Birth Rates of Frozen Embryo Transfer Cycles · completed
- NCT06722313 — Optimized PGT-M Strategy for Patients With No Proband · NA · enrolling by invitation
- NCT05447208 — Effect of GH on the Blastocyst Euploid Rate in AMA Patients · Phase 3 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03940495 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by ShangHai Ji Ai Genetics & IVF Institute
- Last refreshed: 18 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03940495.
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