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NCT03938363: GAIT-TOX
Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia
NA trial testing Treadmill in Cervical Dystonia, Primary in 40 participants. Completed in 13 June 2022.
13 June 2022
Quick facts
| Lead sponsor | University Hospital, Grenoble |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 23 October 2019 |
| Primary completion | 13 June 2022 |
| Estimated completion | 13 June 2022 |
| Sites | 1 location across France |
Drugs / interventions tested
- Treadmill
- Botulinum Toxin injection
- Severity scale of the disease
Conditions studied
- Cervical Dystonia, Primary — all drugs for Cervical Dystonia, Primary →
- Blepharospasm — all drugs for Blepharospasm →
Sponsor
University Hospital, Grenoble
Who can join
18 and older, any sex, with Cervical Dystonia, Primary or Blepharospasm. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Efficient gait requires effective postural control, both static and dynamic. Hence, postural disorders may affect gait. Yet, very little is known about the specific effects of focal postural disorders such as cervical dystonia (CD) and blepharospasm (BS) on patients' mobility. The present research therefore aims at analyzing gait characteristics in patients presenting with these conditions in order to document possible gait alterations. In addition, the investigators will explore the effect of botulinum toxin treatment, which the most frequently used therapeutic option, on the patients' gait characteristics. Indeed, while the treatment improves both dystonia and pain, and therefore quality of life, its influence on gait is presently unknown. the investigators aim at filling this knowledge gap
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Treatment of Dystonia: Medications, Neurotoxins, Neuromodulation, and Rehabilitation.
Bledsoe IO, Viser AC, San Luciano M. · · 2020 · cited 34× · PMID 33095402 · DOI 10.1007/s13311-020-00944-0
Verify or expand the search:
- PubMed search for NCT03938363
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03938363 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Grenoble
- Last refreshed: 22 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03938363.
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