NCT03938168 (PAIN PAD) is a clinical trial of Biopsy, fecal sample in Tissue Adhesion, sponsored by Radboud University Medical Center.

Who is sponsoring NCT03938168?

NCT03938168 is sponsored by Radboud University Medical Center.

What drugs are being tested in NCT03938168?

Interventions in NCT03938168: Biopsy, fecal sample.

What condition does NCT03938168 study?

NCT03938168 studies Tissue Adhesion, Chronic Pain, Surgery.

Is NCT03938168 still recruiting?

NCT03938168 is currently completed. Last updated 31 December 2024.

Last reviewed 2024-12-31 · How we verify

NCT03938168: PAIN PAD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Histological and Molecular Mechanisms of Pain in Patient With Chronic Pain From Adhesions

Completed Last updated 31 December 2024

What this trial tests

trial testing Biopsy, fecal sample in Tissue Adhesion in 61 participants. Completed in 20 December 2024.

Timeline

9 April 2019

Primary endpoint
31 December 2023

20 December 2024

Quick facts

Lead sponsor	Radboud University Medical Center
Status	Completed
Study type	OBSERVATIONAL
Enrollment	61
Start date	9 April 2019
Primary completion	31 December 2023
Estimated completion	20 December 2024
Sites	3 locations across Netherlands

Drugs / interventions tested

Biopsy, fecal sample

Conditions studied

Tissue Adhesion — all drugs for Tissue Adhesion →
Chronic Pain — all drugs for Chronic Pain →
Surgery — all drugs for Surgery →

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with Tissue Adhesion or Chronic Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

11-20% of patients undergoing abdominal surgery develop chronic abdominal pain. Adhesions are a common cause of chronic pain following surgery. Adhesions develop after up to 90% of laparotomies and 70% of laparoscopic surgeries. Obviously, not all adhesions cause pain. It is still poorly understood why adhesions cause pain in some patients, while other patients with adhesions experience no pain. In this study we explore possible mechanism through which adhesions might cause pain. For this purpose we will assess expression of molecular mediators (such as TRPV-1, SP, and the neurokinin receptor), histological characteristics, and fecal microbioma that might be associated with pain.Expression of these factor will be compared to sample from 30 patients with chronic pain attributed to adhesions, and 30 patients undergoing a reoperation with adhsiolysis for reasons unrelated to pain.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Genome-wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank.
Li S, Toneman MK, Mangnus JPM, Strocchi S, et al · · 2025 · cited 2× · PMID 39734325 · DOI 10.1111/anae.16528
Morphological features and molecular mechanisms in peritoneal adhesions from patients with chronic abdominal postoperative pain.
Toneman MK, Marianne Faas PP, Christian Antoine Marie Gielen MJ, Carotti V, et al · · 2025 · cited 1× · PMID 40412079 · DOI 10.1016/j.ebiom.2025.105746

Verify or expand the search:

Other Radboud University Medical Center trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03938168 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
Last refreshed: 31 December 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03938168.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing