NCT03936517 (PRED-AID) is a Phase 3 clinical trial of Prednisolone in Adrenal Insufficiency, sponsored by Imperial College London.

Who is sponsoring NCT03936517?

NCT03936517 is sponsored by Imperial College London.

What drugs are being tested in NCT03936517?

Interventions in NCT03936517: Prednisolone, Hydrocortisone.

What condition does NCT03936517 study?

NCT03936517 studies Adrenal Insufficiency.

Is NCT03936517 still recruiting?

NCT03936517 is currently status unknown. Last updated 1 September 2023.

Last reviewed 2023-09-01 · How we verify

NCT03936517: PRED-AID

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)

Status unknown Phase 3 Last updated 1 September 2023

What this trial tests

Phase 3 trial testing Prednisolone in Adrenal Insufficiency in 44 participants. Status unknown.

Timeline

31 July 2019

Primary endpoint
1 February 2025

1 February 2025

Quick facts

Lead sponsor	Imperial College London
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	44
Start date	31 July 2019
Primary completion	1 February 2025
Estimated completion	1 February 2025
Sites	1 location across United Kingdom

Drugs / interventions tested

Prednisolone — full drug profile →
Hydrocortisone (hydrocortisone) — full drug profile →

Conditions studied

Adrenal Insufficiency — all drugs for Adrenal Insufficiency →

Sponsor

Imperial College London

Who can join

Adults 18 to 70, any sex, with Adrenal Insufficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study compares low-dose prednisolone therapy against standard regimens of hydrocortisone therapy for the treatment of adrenal insufficiency (AI). AI is a condition in which, individuals are unable to sufficiently produce the natural stress hormone, cortisol.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Optimising prednisolone or prednisone replacement in adrenal insufficiency.
Sharma A, Lazarus K, Papadopoulou D, Prabhudev H, et al · · 2023 · cited 10× · PMID 37289726 · DOI 10.1530/ec-23-0097
Prednisolone Once Daily vs Hydrocortisone Thrice Daily in Hypoadrenalism: A Randomized Clinical Trial.
Choudhury S, Lazarus K, Sharma A, Narula K, et al · · 2026 · PMID 41874506 · DOI 10.1001/jamanetworkopen.2026.2982

Verify or expand the search:

Other trials of Prednisolone

Trials testing the same drug.

NCT07072585 — Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leuk · Phase 2, PHASE3 · not yet recruiting
NCT07210008 — "Randomized Controlled Trial Testing the Efficacy of Corticosteroid Therapy Versus Placebo in Fibrotic Hypersensitivity · Phase 3 · not yet recruiting
NCT06953791 — Comparison of Quality of Life During a Flare of Crohn's Disease Treated With Prednisolone or aCDED With PEN in Adult Pat · Phase 2 · recruiting
NCT07052929 — Study of ASP2957 in Male Participants With X-linked Myotubular Myopathy Who Need Ventilators · Phase 1, PHASE2 · recruiting
NCT07252271 — Very Low Dose Prednisolone on Newly Diagnosed Rheumatoid Arthritis · Phase 4 · not yet recruiting

Other recruiting trials for Adrenal Insufficiency

Currently open trials in the same condition.

NCT07168122 — Establishment and Clinical Application of Reference Intervals of Salivary Cortisol · recruiting
NCT06955286 — Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Witho · recruiting
NCT06861530 — A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymp · recruiting
NCT05435781 — Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency · Phase 4 · recruiting
NCT05149638 — Updated Diagnostic Cortisol Values for Adrenal Insufficiency · NA · recruiting

Other Imperial College London trials

Trials by the same sponsor.

NCT06035861 — Endothelial Cell Activation and Total Pulmonary Resistance in PAH · NA · not yet recruiting
NCT07397455 — Development of a Controlled Human Infection Model for Assessment of SARS-CoV-2 Omicron Subvariants · Phase 1 · not yet recruiting
NCT07422532 — A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing · NA · not yet recruiting
NCT07389031 — Maralixibat for Intrahepatic Cholestasis of Pregnancy · Phase 2 · not yet recruiting
NCT07358897 — Gender Affirming Hormone Therapy and Immune Function in Trans Individuals - The GIFT Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03936517 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Imperial College London
Last refreshed: 1 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03936517.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing