NCT03935438: CARDIO-REH

The Influence of Cardiac Rehabilitation on the Health State After ACS

Status unknown NA Last updated 29 April 2020

What this trial tests

NA trial testing Cardiac rehabilitation in Cardiac Rehabilitation in 200 participants. Status unknown.

Timeline

12 April 2019

Primary endpoint
31 December 2024

31 December 2024

Quick facts

Lead sponsor	Poznan University of Medical Sciences
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	200
Start date	12 April 2019
Primary completion	31 December 2024
Estimated completion	31 December 2024
Sites	1 location across Poland

Drugs / interventions tested

• Cardiac rehabilitation

Conditions studied

• Cardiac Rehabilitation — all drugs for Cardiac Rehabilitation →
• Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →

Sponsor

Poznan University of Medical Sciences

Who can join

Adults 18 to 99, any sex, with Cardiac Rehabilitation or Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Coronary heart disease, including acute coronary syndromes (ACS), is the leading cause of death in European countries. One of the basic elements of secondary and tertiary prevention of ACS is cardiac rehabilitation.

The aims of the study are evaluation of the impact of cardiac rehabilitation on health state- especially on cardiovascular function parameters in patients after acute coronary syndrome and evaluation of the influence of the level of gene expression and polymorphisms of genes associated with ischemic heart disease on the course of cardiac rehabilitation in patients after ACS.

The study will consist of a retrospective and prospective part. The retrospective part will include patients who have had acute coronary syndrome in the past and then - before being included in the study - have undergone cardiac rehabilitation. In the retrospective part, patients enrolled in the study will not undergo cardiac rehabilitation as a part of the study intervention. The prospective part will include patients who have had an acute coronary syndrome in the past and will undergo cardiac rehabilitation as the study intervention.

After being included in the study, patients will undergo medical examination. Then subsequent procedures will be performed: anthropometric measurements; ECG; body composition analysis by bioimpedance; measurement of resting blood pressure, resting heart rate and oxygen saturation of hemoglobin; pulse wave analysis; transthoracic echocardiography of the heart; 24-hour blood pressure measurement by ambulatory blood pressure monitoring (ABPM); 24-hour ECG recording using the Holter method; electrocardiographic exercise test on a treadmill and / or a six-minute walk test or other exercise test adequate to the patient's state of health; assessment of the quality of the diet; assessment of lifestyle, acceptance of disease and quality of life; assessment of the psychological profile.

Subsequently patients taking part in the prospective part of the study will perform a cardiac rehabilitation program.

After the cardiac rehabilitation program measurement procedures listed above will be repeated.

Before and after the cardiac rehabilitation program blood samples, urine samples and hair samples will be collected. Blood samples, urine samples and hair samples will also be collected from patients taking part in the retrospective part of the study.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Cardiac rehabilitation may influence leptin and VEGF A crosstalk in patients after acute coronary syndrome.
   Skrypnik D, Skrypnik K, Suliburska J, Bogdański P. · · 2022 · cited 5× · PMID 35821400 · DOI 10.1038/s41598-022-16053-1
2. Cardiac rehabilitation influences serum myokine levels in patients after acute coronary syndrome: the randomised CARDIO-REH study.
   Skrypnik D, Skrypnik K, Granell JC, Woszczyk D, et al · · 2025 · PMID 41198895 · DOI 10.1038/s41598-025-22897-0