18 and older, female only, with Perinatal Depression. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change in Depressive Symptoms Over TimePrimary· Time 1 = pre-intervention (Baseline); T2 = immediately following week 9 of group intervention classes (Post), T3= 2 months post-intervention; T4= 4 months post-intervention; T5 = 6 months post-intervention; T6 = 8 post-intervention
Self-completed: Edinburgh Postnatal Depression Scale measures depression symptoms during pregnancy and postpartum. The instrument will measure depressive symptoms at 6 time points during pregnancy and postpartum. The instrument is on a scale of 0-30, with 0 indicating no symptoms, and 30 indicating the highest severity of symptoms. Scores \< 10 = no depressive symptoms; 10-15 = mild; 16-20 = moderate; \> 20 = severe.
Baseline
Group
Value
95% CI
UPLIFT Program
11.11
± 3.85
Pregnancy Skills Group
10.52
± 4.52
Post
Group
Value
95% CI
UPLIFT Program
7.34
± 2.79
Pregnancy Skills Group
7.69
± 3.92
2 months
Group
Value
95% CI
UPLIFT Program
8.84
± 3.45
Pregnancy Skills Group
8.90
± 5.31
4 months
Group
Value
95% CI
UPLIFT Program
8.52
± 4.62
Pregnancy Skills Group
7.10
± 4.80
6 months
Group
Value
95% CI
UPLIFT Program
8.16
± 5.52
Pregnancy Skills Group
6.35
± 4.49
8 months
Group
Value
95% CI
UPLIFT Program
6.70
± 2.90
Pregnancy Skills Group
6.33
± 3.88
Change in Anxiety Symptoms Over TimeSecondary· Time 1 = pre-intervention; T2 = immediately following week 9 of group intervention classes (post-intervention), T3= 2 months post-intervention; T4= 4 months post-intervention; T5 = 6 months post-intervention; T6 = 8 post-intervention
Self-completed: Generalized Anxiety Disorder - 7 Item scale measures symptoms of anxiety. The instrument will measures anxiety symptoms at 6 time points during pregnancy and postpartum. The instrument is on a scale of 0-21, with 0 indicating no symptoms, and 21 indicating the highest severity of symptoms. Scores of \< 5 = no anxiety; 5-9 = mild; 10-14 = moderate; \> 15 = severe.
Baseline
Group
Value
95% CI
UPLIFT Program
6.97
± 3.01
Pregnancy Skills Group
6.97
± 3.01
Post
Group
Value
95% CI
UPLIFT Program
5.17
± 3.34
Pregnancy Skills Group
5.17
± 3.34
2 months
Group
Value
95% CI
UPLIFT Program
6.31
± 4.04
Pregnancy Skills Group
6.31
± 4.04
4 months
Group
Value
95% CI
UPLIFT Program
5.45
± 3.34
Pregnancy Skills Group
5.45
± 3.34
6 months
Group
Value
95% CI
UPLIFT Program
4.74
± 4.18
Pregnancy Skills Group
4.74
± 4.18
8 months
Group
Value
95% CI
UPLIFT Program
4.35
± 2.68
Pregnancy Skills Group
4.35
± 2.68
Sponsor's own description
The goal of the project is to evaluate for the first time, the effectiveness of using a telehealth approach to reducing perinatal depressive symptoms in diverse groups of childbearing women; urban and rural-dwelling, and from Hispanic and predominantly North European Descent populations. Pregnant women connect for one hour weekly, for 8 weeks, using their own electronic device, from whatever location they choose (e.g. home), to attend videoconference groups facilitated by a mental health professional. The approach is cost effective and reduces barriers to access to mental health services, particularly for women living in rural, low-resource, and minority communities, and those without adequate transportation, financial resources, childcare, or work release time.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Utah
Last refreshed: 4 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03932760.