Who is sponsoring NCT03931161?

NCT03931161 is sponsored by Imperial College Healthcare NHS Trust.

What drugs are being tested in NCT03931161?

Interventions in NCT03931161: Evolocumab Auto-Injector [Repatha], Placebo Auto-Injector.

What condition does NCT03931161 study?

NCT03931161 studies Carotid Artery Stenosis.

Is NCT03931161 still recruiting?

NCT03931161 is currently status unknown. Last updated 13 October 2022.

Last reviewed 2022-10-13 · How we verify

NCT03931161: EVOCAR-1

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis (EVOCAR-1)

Status unknown Phase 4 Last updated 13 October 2022

What this trial tests

Phase 4 trial testing Evolocumab Auto-Injector [Repatha] in Carotid Artery Stenosis in 33 participants. Status unknown.

Timeline

4 September 2019

Primary endpoint
6 May 2023

6 May 2024

Quick facts

Lead sponsor	Imperial College Healthcare NHS Trust
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	33
Start date	4 September 2019
Primary completion	6 May 2023
Estimated completion	6 May 2024
Sites	1 location across United Kingdom

Drugs / interventions tested

Evolocumab Auto-Injector [Repatha] — full drug profile →
Placebo Auto-Injector — full drug profile →

Conditions studied

Carotid Artery Stenosis — all drugs for Carotid Artery Stenosis →

Sponsor

Imperial College Healthcare NHS Trust

Who can join

18 and older, any sex, with Carotid Artery Stenosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a phase IV, randomised, placebo-controlled, double-blind, parallel group study to determine the effect of Evolocumab treatment on carotid plaque morphology and composition in asymptomatic patients with \>50% carotid artery stenosis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Recent Advances on the Roles of PCSK-9 Inhibitors in the Management of Acute Ischemic Stroke Patients.
Ilut S, Pirlog BO, Pirlog R, Nutu A, et al · · 2022 · cited 7× · PMID 36142135 · DOI 10.3390/ijms231810221

Verify or expand the search:

Other recruiting trials for Carotid Artery Stenosis

Currently open trials in the same condition.

NCT07370246 — CAS for Stenosis With High-risk Features for CEA · NA · recruiting
NCT07247864 — Balloon Guide Catheter Combined With Filter Protection for Carotid Artery Stenting · NA · recruiting
NCT06924593 — Study on the Trans-Carotid Artery Occlusion Shunt System · NA · recruiting
NCT07034157 — A Real-World Study on Ultrasound-Based Screening and Integrated Therapeutic Strategies for Patients With Concomitant Cor · recruiting
NCT06936176 — Prospective Trial of IVL for Calcified Carotid Lesions(CREATE Trial) · NA · recruiting

Other Imperial College Healthcare NHS Trust trials

Trials by the same sponsor.

NCT07474584 — OpRESTORE AI-Patient Navigator Study · NA · not yet recruiting
NCT07191678 — Mechanisms Affecting the Gut of Preterm Infants Receiving Blood Transfusion With Different Enteral Feed Interventions · recruiting
NCT06501846 — Pipelle® Under Ultrasound Guidance (PUG) to Investigate Post-menopausal Bleeding. · NA · recruiting
NCT04904484 — A Safety Assessment of the iZephyr Hood for NIV in COVID-19 Patients · NA · unknown
NCT06355570 — Delirium After Cardiac Surgery in Intensive Care Units · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03931161 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Imperial College Healthcare NHS Trust
Last refreshed: 13 October 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03931161.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing