NCT03930459 (ORGANOXLAFE) is a NA clinical trial of Static cold storage (SCS) in Liver Transplant, sponsored by Instituto de Investigacion Sanitaria La Fe.

Who is sponsoring NCT03930459?

NCT03930459 is sponsored by Instituto de Investigacion Sanitaria La Fe.

What drugs are being tested in NCT03930459?

Interventions in NCT03930459: Static cold storage (SCS), Normothermic machine perfusion (NMP).

What condition does NCT03930459 study?

NCT03930459 studies Liver Transplant.

Is NCT03930459 still recruiting?

NCT03930459 is currently terminated. Last updated 29 September 2023.

Last reviewed 2023-09-29 · How we verify

NCT03930459: ORGANOXLAFE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy of Ex-situ Normothermic Perfusion Versus Cold Storage in the Transplant With Steatotic Liver Graft.

Terminated NA Last updated 29 September 2023

What this trial tests

NA trial testing Static cold storage (SCS) in Liver Transplant in 7 participants. Terminated before completion.

Timeline

26 April 2019

Primary endpoint
4 April 2023

4 April 2023

Quick facts

Lead sponsor	Instituto de Investigacion Sanitaria La Fe
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	7
Start date	26 April 2019
Primary completion	4 April 2023
Estimated completion	4 April 2023
Sites	1 location across Spain

Drugs / interventions tested

Static cold storage (SCS)
Normothermic machine perfusion (NMP)

Conditions studied

Liver Transplant — all drugs for Liver Transplant →

Sponsor

Instituto de Investigacion Sanitaria La Fe — full company profile →

Who can join

18 and older, any sex, with Liver Transplant. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Prospective, randomized, controlled clinical trial to determine the overall efficacy of normothermic machine perfusion (NMP) for steatotic liver preservation versus traditional static cold storage (SCS), in 50 liver transplant recipients with 1-year follow-up.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Machine perfusion in liver transplantation.
Tingle SJ, Dobbins JJ, Thompson ER, Figueiredo RS, et al · · 2023 · cited 33× · PMID 37698189 · DOI 10.1002/14651858.cd014685.pub2
Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes.
Matar AJ, Crepeau RL, Mundinger GS, Cetrulo CL, et al · · 2021 · cited 15× · PMID 34276656 · DOI 10.3389/fimmu.2021.664577

Verify or expand the search:

Other recruiting trials for Liver Transplant

Currently open trials in the same condition.

NCT06254248 — Safety of Atezolizumab-Bevacizumab in Liver Transplanted Patients With Advanced Hepatocellular Carcinoma · Phase 2 · recruiting
NCT06832189 — EVR and EPO for Liver Transplant Tolerance · Phase 1 · recruiting
NCT07216508 — Liver Transplant CGM · recruiting
NCT07086989 — Cardiovascular Risk in Children With Chronic Conditions Study · recruiting
NCT06813508 — Prognostic Factors for HCC and Liver Transplantation in Patients With MASLD/MASH · recruiting

Other Instituto de Investigacion Sanitaria La Fe trials

Trials by the same sponsor.

NCT07402083 — Administration of Extracellular Vesicles From Donor Human Milk in Preterm Infants · recruiting
NCT07238608 — Impact of UFPs and MNPs on Fetal Health · recruiting
NCT06950996 — A Clinical Evaluation of AI Solutions Developed in the CHAIMELEON Project for Cancer: Prostate, Lung, Breast, Colon and · completed
NCT06866769 — Efficacy of Biomarkers and CEUS Versus CTA in AAA Follow-up Post-EVAR · recruiting
NCT07478445 — Home Rehabilitation After Hip Fracture · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03930459 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Instituto de Investigacion Sanitaria La Fe
Last refreshed: 29 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03930459.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing