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NCT03929458
Association of Uremic Sarcopenia and Mitochondrial Copy Number and Its Clinical Correlates
trial in Sarcopenia in 160 participants. Completed in 31 December 2019.
31 December 2019
Quick facts
| Lead sponsor | Tungs' Taichung Metroharbour Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 160 |
| Start date | 7 May 2019 |
| Primary completion | 31 December 2019 |
| Estimated completion | 31 December 2019 |
| Sites | 1 location across Taiwan |
Conditions studied
- Sarcopenia — all drugs for Sarcopenia →
- Mitochondrial DNA — all drugs for Mitochondrial DNA →
Sponsor
Tungs' Taichung Metroharbour Hospital
Who can join
Adults 20 to 90, any sex, with Sarcopenia or Mitochondrial DNA. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy. The two factors may interfere with the balance between protein synthesis and breakdown, cause mitochondrial dysfunction, and induce apoptosis. Sarcopenia, inflammation and oxidative stress is highly prevalent in hemodialysis patients and may contribute to mortality. The copy number of mitochondrial DNA (mtDNA) is affected by oxidative stress in blood circulation. This study aimed to test whether mtDNA copy number correlates with oxidative stress and some uremic toxins in nondiabetic hemodialysis(HD) patients. 200 nondiabetic hemodialysis patients and 50 healthy subjects will be enrolled. This study will be performed to investigate quantitative changes in mtDNA occur in HD patients with and without sarcopenia. Copy number of mtDNA in leukocyte DNA is determined by real-time polymerase chain reaction in HD patients and 50 age- and sex-matched control subjects. In addition, correlation of the alterations of albumin redox status, 8-isoprostane, plasma IL-6 ,LBP and TNF-a and as well as various uremic toxins will be performed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities.
Hu H, Guo L, Overholser J, Wang X. · · 2022 · cited 53× · PMID 36231136 · DOI 10.3390/cells11193174
Verify or expand the search:
- PubMed search for NCT03929458
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Sarcopenia
Currently open trials in the same condition.
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- NCT07426159 — AI-Guided Sarcopenia Risk Assessment and Detection · NA · active not recruiting
Other Tungs' Taichung Metroharbour Hospital trials
Trials by the same sponsor.
- NCT07443280 — Alterations of Gut Derived Uremic Toxins and Microbiome Metabolites by Multispecies Synbiotic · NA · not yet recruiting
- NCT07461233 — Modulation of Gut Microbiota Composition and Gut Permeability Profiles by Multispecies Synbiotic Supplementation in Hemo · NA · not yet recruiting
- NCT06877585 — Association Between Fecal Microbiota Composition, Metabolite Concentrations, and Indoxyl Sulfate Levels · recruiting
- NCT06211244 — Association of Serum Eotaxin Levels and Markers of Myocardiac Injury in Hemodialysis Patients · completed
- NCT06206694 — Serum YKL-40 Levels is Associated With Nutritional and Oxidative Status of Hemodialysis Patients · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03929458 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tungs' Taichung Metroharbour Hospital
- Last refreshed: 11 March 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03929458.
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