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NCT03928236: B-Free
Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium
NA trial testing Limited Intraoperative Benzodiazepine in Delirium in 15,886 participants. Participants enrolled and being followed up; not accepting new ones.
11 December 2022
Quick facts
| Lead sponsor | Population Health Research Institute |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 15,886 |
| Start date | 18 November 2019 |
| Primary completion | 11 December 2022 |
| Estimated completion | 30 April 2025 |
| Sites | 20 locations across Canada, United States |
Drugs / interventions tested
- Limited Intraoperative Benzodiazepine
- Liberal Intraoperative Benzodiazepine
Conditions studied
- Delirium — all drugs for Delirium →
- Post-cardiac Surgery — all drugs for Post-cardiac Surgery →
Sponsor
Population Health Research Institute
Who can join
18 and older, any sex, with Delirium or Post-cardiac Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
B-FREE is a pragmatic, multicentre, cluster crossover trial evaluating whether a policy limiting the use of intra-operative benzodiazepine reduces post-operative delirium when compared with a policy of 'ad libitum' administration. The knowledge generated by this study will provide the basis for cardiac anesthesia practice guidelines.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03928236
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Delirium
Currently open trials in the same condition.
- NCT07348471 — Fecal Microbiota Transplantation for the Treatment of ICU Delirium · NA · recruiting
- NCT06969287 — Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery · Phase 3 · recruiting
- NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting
- NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
- NCT07136207 — Development and Validation of Delirium Recognition Using Computer Vision in Neuro-critical Patients · recruiting
Other Population Health Research Institute trials
Trials by the same sponsor.
- NCT07511543 — Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy · Phase 2 · not yet recruiting
- NCT07468448 — Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe · Phase 3 · not yet recruiting
- NCT06587737 — Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage · Phase 3 · not yet recruiting
- NCT07011095 — DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial · EARLY_PHASE1 · not yet recruiting
- NCT06508164 — International CRDS Registry · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03928236 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Population Health Research Institute
- Last refreshed: 4 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03928236.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing