Who is sponsoring NCT03927794?

NCT03927794 is sponsored by Ain Shams University.

What drugs are being tested in NCT03927794?

Interventions in NCT03927794: Self-Assembling Peptide P11-4.

What condition does NCT03927794 study?

NCT03927794 studies White Spot Lesions [Initial Caries] on Smooth Surface of Tooth.

Is NCT03927794 still recruiting?

NCT03927794 is currently completed. Last updated 15 December 2021.

Last reviewed 2021-12-15 · How we verify

NCT03927794

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Remineralization of White Spot Lesions Using Self-Assembling Peptide P11-4 in Primary Anterior Teeth A Randomized Clinical Trial

Completed NA Last updated 15 December 2021

What this trial tests

NA trial testing Self-Assembling Peptide P11-4 in White Spot Lesions [Initial Caries] on Smooth Surface of Tooth in 11 participants. Completed in 1 September 2021.

Timeline

1 September 2020

Primary endpoint
1 September 2021

1 September 2021

Quick facts

Lead sponsor	Ain Shams University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	11
Start date	1 September 2020
Primary completion	1 September 2021
Estimated completion	1 September 2021
Sites	1 location across Egypt

Drugs / interventions tested

Self-Assembling Peptide P11-4

Conditions studied

White Spot Lesions [Initial Caries] on Smooth Surface of Tooth — all drugs for White Spot Lesions [Initial Caries] on Smooth Surface of Tooth →

Sponsor

Ain Shams University

Who can join

Adults 3 to 5, any sex, with White Spot Lesions [Initial Caries] on Smooth Surface of Tooth. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a randomized controlled clinical trial on primary anterior teeth of 3-5 year-old patients suffering from white spot lesions (ICDAS system II scores 1-2). Forty four teeth will be divided into two groups where Group 1 (n=22 teeth) will receive Self-Assembling Peptide P11-4. Group 2 (n=22 teeth) will receive Topical Fluoride Varnish Application. Assessment will be done at baseline using the International Caries Detection and Assessment System II (ICDAS II) scoring system and Light Induced Fluorescence using Soprolife System (Acteon, La Ciotat, France) and then after 3 months, 6 months and 1 year. The assessment of the baseline and follow up data will be performed by the main investigator.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.
Gray VP, Amelung CD, Duti IJ, Laudermilch EG, et al · · 2022 · cited 47× · PMID 34710626 · DOI 10.1016/j.actbio.2021.10.030

Verify or expand the search:

Other recruiting trials for White Spot Lesions [Initial Caries] on Smooth Surface of Tooth

Currently open trials in the same condition.

NCT06696105 — Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions · Phase 4 · active not recruiting

Other Ain Shams University trials

Trials by the same sponsor.

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NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03927794 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 15 December 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03927794.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing