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Predictive Factors of Good Pulmonary Penetration of Antibiotics : AntiBiotics Dosage in Broncho-Alveolar Lavage (ABBA)
Respiratory infections are common and sometimes very severe. An insufficient dosage of the antibiotic could lead to a treatment failure A correct plasmatic antibiotic concentration is not a guarantee of a clinical success as it could not be a reflect of pulmonary concentration. The aim of this study is to determinate the predictive factors of pulmonary penetration of antibiotics in patients with a beta lactamines failure and who undergoes a flexible bronchoscopy.
Details
| Lead sponsor | Centre Hospitalier Universitaire, Amiens |
|---|---|
| Phase | NA |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 101 |
| Start date | Tue Apr 23 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Jun 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Antibiotics
- Pneumonia
Interventions
- measure of intra-alveolar antibiotic concentration in µg/ml
- broncho-alveolar lavage (BAL)
- blood test to measure plasmatic antibiotic concentration in µg/ml
Countries
France