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NCT03926585

Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment

Completed Last updated 25 May 2023
What this trial tests

trial in Hypothyroidism in 82 participants. Completed in 1 August 2022.

Timeline
23 April 2019
Primary endpoint
1 August 2022
1 August 2022

Quick facts

Lead sponsorBirte Nygaard
StatusCompleted
Study typeOBSERVATIONAL
Enrollment82
Start date23 April 2019
Primary completion1 August 2022
Estimated completion1 August 2022
Sites1 location across Denmark

Conditions studied

Sponsor

Birte Nygaard

Who can join

Adults 18 to 80, any sex, with Hypothyroidism. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hypothesis: Variations in the deiodinase 2 gene and monocarboxylate transporter 10 gene is associated with improvement in quality of life after initiation of combination therapy with L-Thyroxine and Liothyronine in patients with persistent hypothyroid symptoms despite conventional L-thyroxine mono-therapy. Purpose: To re-test this hypothesis in patients with continued perceived effect of Liothyronine treatment at least one year after initiation in a patient population more representing of daily clinical practice. The study will help determine whether testing of specific gene variations might predict longtime effect of combination therapy.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

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Other recruiting trials for Hypothyroidism

Currently open trials in the same condition.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03926585.

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