Last reviewed · How we verify
NCT03926585
Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment
trial in Hypothyroidism in 82 participants. Completed in 1 August 2022.
1 August 2022
Quick facts
| Lead sponsor | Birte Nygaard |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 82 |
| Start date | 23 April 2019 |
| Primary completion | 1 August 2022 |
| Estimated completion | 1 August 2022 |
| Sites | 1 location across Denmark |
Conditions studied
- Hypothyroidism — all drugs for Hypothyroidism →
Sponsor
Birte Nygaard
Who can join
Adults 18 to 80, any sex, with Hypothyroidism. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hypothesis: Variations in the deiodinase 2 gene and monocarboxylate transporter 10 gene is associated with improvement in quality of life after initiation of combination therapy with L-Thyroxine and Liothyronine in patients with persistent hypothyroid symptoms despite conventional L-thyroxine mono-therapy. Purpose: To re-test this hypothesis in patients with continued perceived effect of Liothyronine treatment at least one year after initiation in a patient population more representing of daily clinical practice. The study will help determine whether testing of specific gene variations might predict longtime effect of combination therapy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03926585
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hypothyroidism
Currently open trials in the same condition.
- NCT07060118 — Gluten Free Diet in Hashimoto's Hypothyroidism · NA · recruiting
- NCT06757712 — Periodization Resistance Training on Quality of Life in Females With Hypothyroidism · NA · recruiting
- NCT06731764 — Novel Approaches to the Treatment of Hypothyroidism · Phase 2, PHASE3 · recruiting
- NCT06826248 — Clinical Efficacy of Darqeen Capsule for the Management of Hypothyroidism Associated with Female Reproductive Hormonal I · EARLY_PHASE1 · active not recruiting
- NCT07421869 — SNUH Immune Checkpoint Inhibitor-induced Hypothyroidism Recovery Trial · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03926585 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Birte Nygaard
- Last refreshed: 25 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03926585.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing