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NCT03924726
Osseous Evidence Behind Micro-osteoperforation in Accelerating Tooth Movement.
NA trial testing Micro-osteoperforation (MOP) in Orthodontics in 24 participants. Completed in 20 December 2018.
20 November 2018
Quick facts
| Lead sponsor | University of Malaya |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 24 |
| Start date | 10 May 2017 |
| Primary completion | 20 November 2018 |
| Estimated completion | 20 December 2018 |
| Sites | 1 location across Malaysia |
Drugs / interventions tested
- Micro-osteoperforation (MOP)
Conditions studied
- Orthodontics — all drugs for Orthodontics →
Sponsor
University of Malaya
Who can join
18 and older, any sex, with Orthodontics. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Introduction The study aimed to investigate the effects of micro-osteoperforations (MOPs) on the changes in mandibular bone volume fraction (Bone Volume/Total Volume, BV/TV), in relation to the MOP effects on the rate of orthodontic tooth movement, using CBCT images. The other objective was to evaluate the effects of different frequency intervals (4 weeks, 8 weeks and 12 weeks) of MOPs on mandibular bone volume fraction (BV/TV), in relation to the rate of tooth movement. Methods In 24 participants, orthodontic force of 140-200 grams was applied for mandibular canine retraction. Three micro-osteoperforations (MOP's) were made according to the scheduled intervals of the three different groups (4, 8 and 12 weeks) directly at the mandibular buccal cortical bone of extracted first premolars sites. At the 12th week following MOP application, CBCT scans were performed. CT Analyser software was used to compute trabecular alveolar bone volume fraction (BV/TV).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Distribution of mandibular trabeculae bone volume fraction in relation to different MOP intervals for accelerating orthodontic tooth movement.
Teh NHK, Sivarajan S, Asif MK, Ibrahim N, et al · · 2020 · cited 2× · PMID 33378515 · DOI 10.2319/032820-227.1
Verify or expand the search:
- PubMed search for NCT03924726
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03924726 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Malaya
- Last refreshed: 23 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03924726.
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