NCT03918525: DISFIN

Diabetes In Sindhi Families In Nagpur (DISFIN)

Completed Last updated 17 April 2019

What this trial tests

trial testing Sindhi families in Diabetes Mellitus, Type 2 in 1,462 participants. Completed in 20 February 2018.

Timeline

20 February 2017

Primary endpoint
20 February 2018

20 February 2018

Quick facts

Lead sponsor	Lata Medical Research Foundation, Nagpur
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,462
Start date	20 February 2017
Primary completion	20 February 2018
Estimated completion	20 February 2018
Sites	1 location across India

Drugs / interventions tested

• Sindhi families

Conditions studied

• Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →

Sponsor

Lata Medical Research Foundation, Nagpur

Who can join

20 and older, any sex, with Diabetes Mellitus, Type 2. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The pandemic of diabetes is increasing at an alarming rate. The prevalence of diabetes has risen in India by 123% over the last decade. In 1990, diabetes was not considered an important contributor to mortality in India but in 2013, it is ranked as the eighth most common cause of deaths in adult Indian population. There is now a growing understanding that diabetes runs in families and has a significant genetic basis. In this regard, it is noteworthy that from an ethnographic standpoint, Sindhi population in India has been both genetically and environmentally at an increased risk of stress, hypertension and cardiovascular diseases. Considering the nexus of metabolic diseases that include hypertension, obesity, dyslipidemia and diabetes it is therefore expected that this population may be at an increased risk of these metabolic conditions. However, exact prevalence of contributors to type 2 diabetes in the Sindhi population is unknown. The proposed study will estimate prevalence of type 2 diabetes in Sindhi families of Nagpur. Both the PIs have extensive experience with family studies which includes construction of pedigrees, using variance components methods, dissecting out genetic and environmental components of diseases and association of critical phenotypic traits with disease. The proposed study will tap this resource with a focus on the Sindhi families of Nagpur which are concentrated in the Jaripatka and Khamla areas. This study will exploit the current infrastructure in the Lata Medical Research Foundation to access these families and conduct a first-of-its-kind study in India. It is expected that this study will pave way for more extensive genetic, epigenetic and environmental studies of this population. It will also foster future collaborations with national and international health agencies. In that vein, the DISFIN pilot study represents the first step towards identification, quantification, prevention and control of type 2 diabetes in central India.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.
   Mamtani M, Jaisinghani MT, Jaiswal SG, Pipal KV, et al · · 2021 · cited 5× · PMID 34506595 · DOI 10.1371/journal.pone.0257390