Last reviewed · How we verify
NCT03917784
Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes
Phase 4 trial testing Curcumin in PreDiabetes in 142 participants. Status unknown.
30 November 2019
Quick facts
| Lead sponsor | Hospital General de México Dr. Eduardo Liceaga |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 142 |
| Start date | 25 February 2019 |
| Primary completion | 30 November 2019 |
| Estimated completion | 28 February 2020 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
Conditions studied
- PreDiabetes — all drugs for PreDiabetes →
Sponsor
Hospital General de México Dr. Eduardo Liceaga
Who can join
Adults 18 to 60, any sex, with PreDiabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study evaluates the effects of oral supplementation with curcumin on the insulin sensitivity in subjects with prediabetes. The half of participants will receive curcumin and bioperine in combination, while the other half receive placebo.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study.
Wu YL, Lin ZJ, Li CC, Lin X, et al · · 2023 · cited 243× · PMID 36864020 · DOI 10.1038/s41392-023-01333-7 -
Nrf2: The Master and Captain of Beta Cell Fate.
Baumel-Alterzon S, Katz LS, Brill G, Garcia-Ocaña A, et al · · 2021 · cited 81× · PMID 33243626 · DOI 10.1016/j.tem.2020.11.002 -
Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases.
Kim MJ, Jeon JH. · · 2022 · cited 60× · PMID 35269986 · DOI 10.3390/ijms23052846 -
Therapeutic Effect of Curcumin on Metabolic Diseases: Evidence from Clinical Studies.
Zeng Y, Luo Y, Wang L, Zhang K, et al · · 2023 · cited 38× · PMID 36834734 · DOI 10.3390/ijms24043323 -
Pharmacological effects, formulations, and clinical research progress of curcumin.
Hao M, Zhang C, Wang T, Hu H. · · 2025 · cited 9× · PMID 40166470 · DOI 10.3389/fphar.2025.1509045
Verify or expand the search:
- PubMed search for NCT03917784
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Curcumin
Trials testing the same drug.
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- NCT07251985 — Cognitive Effects of Bioavailable Curcumin · Phase 2 · not yet recruiting
- NCT07379177 — Evaluation of the Pharmacokinetics of Curcumin Capsules in Healthy Human · NA · not yet recruiting
- NCT07523256 — Effect of Curcumin Add-On Therapy on Quality of Life and IL-1β Levels in Patients With Schizophrenia · NA · completed
- NCT06531863 — Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance · EARLY_PHASE1 · recruiting
Other recruiting trials for PreDiabetes
Currently open trials in the same condition.
- NCT06897982 — Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center · NA · recruiting
- NCT06967558 — The Role of Islet GLP-1 in the Pathogenesis of Prediabetes · Phase 2 · recruiting
- NCT06482944 — Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes · NA · recruiting
- NCT06989164 — Post Prandial Individual Responses to Different Foods · NA · recruiting
- NCT07254572 — Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes · Phase 4 · recruiting
Other Hospital General de México Dr. Eduardo Liceaga trials
Trials by the same sponsor.
- NCT06786364 — Types of Photoplethysmographic Waves in Adult Patients with Septic Shock · recruiting
- NCT06622538 — Orotracheal Intubation with the ORION Videolaryngoscope Versus the King Vision Videolaryngoscope in Adult Patients: ORIO · NA · completed
- NCT07229924 — Evaluation of Cognitive Improvement After Bariatric Surgery Using a Virtual Reality Program and the Neuropsi Neuropsycho · NA · recruiting
- NCT06318104 — Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs Esomeprazole · Phase 4 · unknown
- NCT04475991 — Safety and Efficacy of Maraviroc and/or Favipiravir With Standard Therapy in Severe COVID-19 Adults · Phase 2 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03917784 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital General de México Dr. Eduardo Liceaga
- Last refreshed: 17 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03917784.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing