NCT03916341 is a NA clinical trial of EC with nicotine in Sudden Cardiac Death, sponsored by University of California, Los Angeles.

Who is sponsoring NCT03916341?

NCT03916341 is sponsored by University of California, Los Angeles.

What drugs are being tested in NCT03916341?

Interventions in NCT03916341: EC with nicotine, EC without nicotine, control, TC with nicotine (own brand), research TC with very low level nicotine.

What condition does NCT03916341 study?

NCT03916341 studies Sudden Cardiac Death, Prolonged QTc Interval.

Is NCT03916341 still recruiting?

NCT03916341 is currently completed. Last updated 4 October 2023.

Last reviewed 2023-10-04 · How we verify

NCT03916341

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Smoking and Ventricular Repolarization

Completed NA Last updated 4 October 2023

What this trial tests

NA trial testing EC with nicotine in Sudden Cardiac Death in 110 participants. Completed in 10 April 2023.

Timeline

1 October 2019

Primary endpoint
10 April 2023

10 April 2023

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	basic science
Enrollment	110
Start date	1 October 2019
Primary completion	10 April 2023
Estimated completion	10 April 2023
Sites	1 location across United States

Drugs / interventions tested

EC with nicotine
EC without nicotine
control
TC with nicotine (own brand)
research TC with very low level nicotine

Conditions studied

Sudden Cardiac Death — all drugs for Sudden Cardiac Death →
Prolonged QTc Interval — all drugs for Prolonged QTc Interval →

Sponsor

University of California, Los Angeles

Who can join

Adults 21 to 45, any sex, with Sudden Cardiac Death or Prolonged QTc Interval. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Electronic cigarettes prolong ventricular repolarization in people who smoke tobacco cigarettes: implications for harm reduction.
Ruedisueli I, Lakhani K, Nguyen R, Gornbein J, et al · · 2023 · cited 8× · PMID 37057991 · DOI 10.1152/ajpheart.00057.2023
Acute cardiovascular effects of 4th generation electronic cigarettes and combusted cigarettes: implications for harm reduction.
Nguyen R, Ruedisueli I, Lakhani K, Ma J, et al · · 2024 · cited 5× · PMID 38205548 · DOI 10.1152/japplphysiol.00067.2023

Verify or expand the search:

Other recruiting trials for Sudden Cardiac Death

Currently open trials in the same condition.

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NCT06546137 — National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Un · recruiting
NCT06771700 — S-ICD Implantation: US Based Pilot Study · NA · recruiting
NCT06954103 — Mechanisms And Prognosis of Stroke-Heart Syndrome · recruiting

Other University of California, Los Angeles trials

Trials by the same sponsor.

NCT04846517 — rTMS for Aneroxia Nervosa in Youth · NA · not yet recruiting
NCT06701760 — Sodium Lactate in Severe TBI · Phase 2 · not yet recruiting
NCT04996667 — Effect of iNO in Patients With Submassive and Massive PE · Phase 2 · withdrawn
NCT05067387 — Evaluation of Oral THC and CBD in Men and Women · Phase 1 · not yet recruiting
NCT07534696 — Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03916341 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Los Angeles
Last refreshed: 4 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03916341.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing