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NCT03913065
Head Computed Tomography for Predicting Neurological Outcome After Cardiac Arrest
trial testing CT in Heart Arrest, Out-Of-Hospital in 400 participants. Completed in 12 March 2023.
31 December 2022
Quick facts
| Lead sponsor | Lund University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 400 |
| Start date | 18 November 2017 |
| Primary completion | 31 December 2022 |
| Estimated completion | 12 March 2023 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- CT
Conditions studied
- Heart Arrest, Out-Of-Hospital — all drugs for Heart Arrest, Out-Of-Hospital →
- Computed Tomography — all drugs for Computed Tomography →
- Unconsciousness — all drugs for Unconsciousness →
- Neurologic Deficits — all drugs for Neurologic Deficits →
Sponsor
Lund University
Who can join
18 and older, any sex, with Heart Arrest, Out-Of-Hospital or Computed Tomography. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) joint guidelines for post-resuscitation care recommend a multimodal approach to prognostication of neurological outcome. However, head computed tomography (CT) which is commonly used for predicting long-term neurological outcome after cardiac arrest has not yet been examined prospectively in a clinical trial. The primary purpose of the TTM-2 CT-substudy is to prospectively investigate and compare various methods of diagnosing generalized oedema on CT after cardiac arrest and it´s ability to predict long-term neurological outcome.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study.
Lang M, Kenda M, Scheel M, Martola J, et al · · 2024 · cited 15× · PMID 38900283 · DOI 10.1007/s00134-024-07497-2 -
Prognostic accuracy of head computed tomography for prediction of functional outcome after out-of-hospital cardiac arrest: Rationale and design of the prospective TTM2-CT-substudy.
Lang M, Leithner C, Scheel M, Kenda M, et al · · 2022 · cited 4× · PMID 36267356 · DOI 10.1016/j.resplu.2022.100316 -
ESICM LIVES 2023.
· 2023 · cited 2× · PMID 37874422 · DOI 10.1186/s40635-023-00546-y -
Radiological signs of hypoxic-ischaemic encephalopathy on head computed tomography for prediction of poor functional outcome after cardiac arrest - a prospective observational cohort study.
Lang M, Kenda M, Scheel M, Martola J, et al · · 2025 · cited 1× · PMID 40499676 · DOI 10.1016/j.resuscitation.2025.110675
Verify or expand the search:
- PubMed search for NCT03913065
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03913065 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lund University
- Last refreshed: 22 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03913065.
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