NCT03912922: SITLESS4

SIT LESS 4: How Does Reducing Sitting Time Improve Glucose and Lipid Metabolism?

Completed NA Last updated 20 January 2021

What this trial tests

NA trial testing Activity regime in Overweight and Obesity in 12 participants. Completed in 13 March 2020.

Timeline

15 December 2017

Primary endpoint
13 March 2020

13 March 2020

Quick facts

Lead sponsor	Maastricht University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	prevention
Enrollment	12
Start date	15 December 2017
Primary completion	13 March 2020
Estimated completion	13 March 2020
Sites	1 location across Netherlands

Drugs / interventions tested

• Activity regime

Conditions studied

• Overweight and Obesity — all drugs for Overweight and Obesity →

Sponsor

Maastricht University Medical Center

Who can join

Adults 45 to 70, female only, with Overweight and Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after sitting all day in combination with 1h streneous exercise.

The main objective of this study is to investigate the underlying mechanisms responsible for improved insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. Our secondary objective is to investigate the effects of sitting less on cardio metabolic parameters.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women.
   Remie CME, Janssens GE, Bilet L, van Weeghel M, et al · · 2021 · cited 20× · PMID 34510226 · DOI 10.1007/s00125-021-05558-5