Who is sponsoring NCT03911908?

NCT03911908 is sponsored by Dr. Serge Thal.

What drugs are being tested in NCT03911908?

Interventions in NCT03911908: Cerebral oximetry (near infrared) based CPR-Algorithm.

What condition does NCT03911908 study?

NCT03911908 studies Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation, Cerebral Oxygenation.

Is NCT03911908 still recruiting?

NCT03911908 is currently status unknown. Last updated 31 March 2023.

Last reviewed 2023-03-31 · How we verify

NCT03911908: NICA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of NIRS-guided Cardiopulmonary Resuscitation After Cardiac Arrest on Resuscitation Rate

Status unknown Phase 2 Last updated 31 March 2023

What this trial tests

Phase 2 trial testing Cerebral oximetry (near infrared) based CPR-Algorithm in Cardiac Arrest in 360 participants. Status unknown.

Timeline

1 July 2019

Primary endpoint
22 May 2022

5 May 2023

Quick facts

Lead sponsor	Dr. Serge Thal
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	360
Start date	1 July 2019
Primary completion	22 May 2022
Estimated completion	5 May 2023
Sites	1 location across Germany

Drugs / interventions tested

Cerebral oximetry (near infrared) based CPR-Algorithm

Conditions studied

Cardiac Arrest — all drugs for Cardiac Arrest →
Cardiopulmonary Arrest With Successful Resuscitation — all drugs for Cardiopulmonary Arrest With Successful Resuscitation →
Cerebral Oxygenation — all drugs for Cerebral Oxygenation →

Sponsor

Dr. Serge Thal

Who can join

18 and older, any sex, with Cardiac Arrest or Cardiopulmonary Arrest With Successful Resuscitation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Sudden cardiac death is one of the main causes of morbidity and mortality worldwide. Cardiac arrest requires prompt intervention by cardiopulmonary resuscitation (CPR). The resuscitation guidelines are the current recommendations for CPR and are revised by expert panels such as the "European Resuscitation Council (ERC)". Up to now, a parameter for assessing the quality of CPR is missing and further monitoring methods are urgently needed. Near-infrared spectroscopy (NIRS) is a portable method for measuring regional oxygen levels in the brain. Recent clinical trials suggest that cerebral oxygenation measured by NIRS may correlate with survival and outcome after cardiac arrest. The investigators propose that NIRS technology may not only be suitable to determine or predict the outcome of the patients, but could also be a useful tool to guide the CPR providers to optimize the CPR techniques and guide the individual treatments/interventions. The present study was therefore designed to determine if NIRS guided CPR with the aim to optimize NIRS values is superior compared to the current standard practice according to published CPR guidelines (return of spontaneous circulation \[ROSC\] rate, short and long-term cerebral performance).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Pediatric Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.
Maconochie IK, Aickin R, Hazinski MF, Atkins DL, et al · · 2020 · cited 45× · PMID 33098916 · DOI 10.1016/j.resuscitation.2020.09.013

Verify or expand the search:

Other recruiting trials for Cardiac Arrest

Currently open trials in the same condition.

NCT07239206 — Serious Game for Improving Targeted Temperature Management Knowledge and Situational Awareness in Critical Care Nurses · NA · recruiting
NCT06780722 — Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Proced · recruiting
NCT06405581 — The Impact of Frailty on Cardiopulmonary Resuscitation Adverse Outcomes in Patients Requiring Code Blue Activation · recruiting
NCT06511999 — Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest · recruiting
NCT07113769 — Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03911908 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Dr. Serge Thal
Last refreshed: 31 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03911908.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing