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NCT03910998
Impact of Intraoperative Deep Neuromuscular Blockade on NOL-guided Opioid Requirement in LSC Colorectal Surgeries
Phase 4 trial testing Rocuronium IV bolus 0.1 mg/kg guided by TOF that must remain between 1-3 during surgery in Laparoscopic Colorectal Surgeries in 100 participants. Status unknown.
1 July 2022
Quick facts
| Lead sponsor | Ciusss de L'Est de l'Île de Montréal |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 30 May 2019 |
| Primary completion | 1 July 2022 |
| Estimated completion | 1 July 2022 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Rocuronium IV bolus 0.1 mg/kg guided by TOF that must remain between 1-3 during surgery — full drug profile →
- Rocuronium IV bolus 0.1 mg/kg guided by TOF 0/4 and PTC≤ 2 — full drug profile →
Conditions studied
- Laparoscopic Colorectal Surgeries — all drugs for Laparoscopic Colorectal Surgeries →
Sponsor
Ciusss de L'Est de l'Île de Montréal — full company profile →
Who can join
18 and older, any sex, with Laparoscopic Colorectal Surgeries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the present study is to answer the question whether deep neuromuscular blockade has a clinically significant impact on intra and postoperative pain, opioid requirement and anesthesia related outcomes and side effects for the early phase of recovery (24hs) after colorectal laparoscopic surgery.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Impact of deep neuromuscular blockade on intraoperative NOL-guided remifentanil requirement during desflurane anesthesia in laparoscopic colorectal surgeries: A randomised controlled trial.
Morisson L, Harkouk H, Othenin-Girard A, Oulehri W, et al · · 2024 · cited 5× · PMID 39447530 · DOI 10.1016/j.jclinane.2024.111659 -
Deep neuromuscular blockade in adults undergoing an abdominal laparoscopic procedure.
Bijkerk V, Jacobs LM, Albers KI, Gurusamy KS, et al · · 2024 · cited 2× · PMID 38288876 · DOI 10.1002/14651858.cd013197.pub2
Verify or expand the search:
- PubMed search for NCT03910998
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03910998 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ciusss de L'Est de l'Île de Montréal
- Last refreshed: 5 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03910998.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing