NCT03910075 (I-ACQUIRE) is a Phase 3 clinical trial of I-ACQUIRE - High Dosage in Perinatal Stroke, sponsored by Virginia Polytechnic Institute and State University.

Who is sponsoring NCT03910075?

NCT03910075 is sponsored by Virginia Polytechnic Institute and State University.

What drugs are being tested in NCT03910075?

Interventions in NCT03910075: I-ACQUIRE - High Dosage, I-ACQUIRE - Moderate Dosage, Usual & Customary Treatment (U&CT).

What condition does NCT03910075 study?

NCT03910075 studies Perinatal Stroke, Hemiparesis.

Is NCT03910075 still recruiting?

NCT03910075 is currently completed. Last updated 16 January 2026.

Last reviewed 2026-01-16 · How we verify

NCT03910075: I-ACQUIRE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)

Completed Phase 3 Last updated 16 January 2026

What this trial tests

Phase 3 trial testing I-ACQUIRE - High Dosage in Perinatal Stroke in 216 participants. Completed in 31 July 2025.

Timeline

10 October 2019

Primary endpoint
31 July 2025

31 July 2025

Quick facts

Lead sponsor	Virginia Polytechnic Institute and State University
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	single
Primary purpose	treatment
Enrollment	216
Start date	10 October 2019
Primary completion	31 July 2025
Estimated completion	31 July 2025
Sites	15 locations across United States

Drugs / interventions tested

I-ACQUIRE - High Dosage
I-ACQUIRE - Moderate Dosage
Usual & Customary Treatment (U&CT)

Conditions studied

Perinatal Stroke — all drugs for Perinatal Stroke →
Hemiparesis — all drugs for Hemiparesis →

Sponsor

Virginia Polytechnic Institute and State University

Who can join

Adults 8 Months to 36 Months, any sex, with Perinatal Stroke or Hemiparesis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant rehabilitation in infants who experienced Perinatal Arterial Stroke (PAS).

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Effect of Motor Intervention for Infants and Toddlers With Cerebral Palsy: A Systematic Review and Meta-analysis.
Baker A, Niles N, Kysh L, Sargent B. · · 2022 · cited 19× · PMID 35671383 · DOI 10.1097/pep.0000000000000914
Optimal Randomization Designs for Large Multicenter Clinical Trials: From the National Institutes of Health Stroke Trials Network Funded by National Institutes of Health/National Institute of Neurological Disorders and Stroke Experience.
Zhao W, Yeatts SD, Broderick JP, Selim MH, et al · · 2023 · cited 6× · PMID 37078281 · DOI 10.1161/strokeaha.122.040743
Parent Council for a Pediatric Stroke Rehabilitation Clinical Trial.
Yale MM, Birch TB, Murray J, Dodds N, et al · · 2024 · cited 2× · PMID 39228362 · DOI 10.1542/peds.2023-064477
Ten years of Central IRB review for an NIH-funded large clinical trial network by an academic IRB: The NIH StrokeNet experience.
Linke M, Braggs-Brown A, Roll SK, Mills K, et al · · 2026 · PMID 41657754 · DOI 10.1017/cts.2025.10231
Perinatal Arterial Ischemic Stroke Phase 3 Trial Protocol for Intensive Infant-Toddler Rehabilitation (I-ACQUIRE).
Ramey SL, Lo WD, DeLuca SC, Heathcock JC, et al · · 2026 · PMID 41649967 · DOI 10.1161/strokeaha.125.053375

Verify or expand the search:

Other Virginia Polytechnic Institute and State University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03910075 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Virginia Polytechnic Institute and State University
Last refreshed: 16 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03910075.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing