Who is sponsoring NCT03909854?

NCT03909854 is sponsored by Wake Forest University Health Sciences.

What drugs are being tested in NCT03909854?

Interventions in NCT03909854: mode of mechanical ventilation.

What condition does NCT03909854 study?

NCT03909854 studies Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Ventilator Lung.

Is NCT03909854 still recruiting?

NCT03909854 is currently completed. Last updated 7 July 2023.

Last reviewed 2023-07-07 · How we verify

NCT03909854: PIVOT-1

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pragmatic Investigation of Volume Targeted Ventilation-1

Completed NA Last updated 7 July 2023

What this trial tests

NA trial testing mode of mechanical ventilation in Respiratory Failure in 139 participants. Completed in 20 February 2020.

Timeline

9 September 2019

Primary endpoint
12 November 2019

20 February 2020

Quick facts

Lead sponsor	Wake Forest University Health Sciences
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	139
Start date	9 September 2019
Primary completion	12 November 2019
Estimated completion	20 February 2020
Sites	1 location across United States

Drugs / interventions tested

mode of mechanical ventilation

Conditions studied

Respiratory Failure — all drugs for Respiratory Failure →
Acute Respiratory Distress Syndrome (ARDS) — all drugs for Acute Respiratory Distress Syndrome (ARDS) →
Ventilator Lung — all drugs for Ventilator Lung →

Sponsor

Wake Forest University Health Sciences

Who can join

18 and older, any sex, with Respiratory Failure or Acute Respiratory Distress Syndrome (ARDS). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This proposal will test the feasibility of implementing an assist volume control ventilation protocol in patients receiving mechanical ventilation in the medical intensive care unit. The trial will consist of a before-and-after trial design of block assignment to either adaptive pressure control (baseline) or assist volume control . This is a feasibility study looking at the management of patients in the ventilator.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A Pragmatic Pilot Trial Comparing Patient-Triggered Adaptive Pressure Control to Patient-Triggered Volume Control Ventilation in Critically Ill Adults.
Gibbs KW, Forbes JL, Harrison KJ, Krall JT, et al · · 2023 · cited 4× · PMID 36944477 · DOI 10.4187/respcare.10803

Verify or expand the search:

Other recruiting trials for Respiratory Failure

Currently open trials in the same condition.

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Other Wake Forest University Health Sciences trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03909854 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Wake Forest University Health Sciences
Last refreshed: 7 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03909854.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing