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Thinking Zinc: A Study of Zinc Supplementation to Ameliorate Adverse Effects of Mine Waste Exposure on the Navajo Nation
This is a study to assess the effect of dietary zinc supplementation to mitigate biomarkers of metal toxicity in exposed tribal populations.
Details
| Lead sponsor | University of New Mexico |
|---|---|
| Phase | NA |
| Status | RECRUITING |
| Enrolment | 100 |
| Start date | 2019-05-19 |
| Completion | 2027-12 |
Conditions
- DNA Damage
- Immune System Disorder
Interventions
- Zinc Picolinate 15 Mg
Primary outcomes
- Metal biomonitoring to compare change from baseline versus zinc supplement — Visit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)
urinary and serum metal levels to be measured by inductively coupled plasma mass spectrometry - Lymphocyte phenotyping to compare change from baseline versus zinc supplement — Visit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)
Lymphocyte phenotypes will be measured in blood samples - Cytokine level measurement to compare change from baseline versus zinc supplement — Visit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)
A cytokine panel will be used to measure levels of multiple cytokines in blood samples - Autoantibody measurement to compare change from baseline versus zinc supplement — Visit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)
Autoantibody panel titers will be measured in blood samples
Countries
United States