NCT03907631 (ELEVATE-ASUC) is a clinical trial of Standard of care in Severe Ulcerative Colitis, sponsored by Hull University Teaching Hospitals NHS Trust.

Who is sponsoring NCT03907631?

NCT03907631 is sponsored by Hull University Teaching Hospitals NHS Trust.

What drugs are being tested in NCT03907631?

Interventions in NCT03907631: Standard of care.

What condition does NCT03907631 study?

NCT03907631 studies Severe Ulcerative Colitis.

Is NCT03907631 still recruiting?

NCT03907631 is currently active, enrolled. Last updated 17 February 2026.

Last reviewed 2026-02-17 · How we verify

NCT03907631: ELEVATE-ASUC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)

Active, enrolled Last updated 17 February 2026

What this trial tests

trial testing Standard of care in Severe Ulcerative Colitis in 189 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

18 October 2019

Primary endpoint
31 January 2024

31 August 2026

Quick facts

Lead sponsor	Hull University Teaching Hospitals NHS Trust
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	189
Start date	18 October 2019
Primary completion	31 January 2024
Estimated completion	31 August 2026
Sites	1 location across United Kingdom

Drugs / interventions tested

Standard of care

Conditions studied

Severe Ulcerative Colitis — all drugs for Severe Ulcerative Colitis →

Sponsor

Hull University Teaching Hospitals NHS Trust

Who can join

Adults 18 to 80, any sex, with Severe Ulcerative Colitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Up to one third of patients with Ulcerative Colitis (UC) will require hospitalisation for severe disease (ASUC - Acute Severe Ulcerative Colitis), often within the first 12 months of diagnosis. 30-40% of people admitted to hospital with ASUC will require colectomy during the emergency admission. Investigators will develop a multi-centre prospective inception cohort of patients with ASUC with homogeneously collected detailed longitudinal clinical, endoscopic and laboratory data.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.
Sebastian S, Walker GJ, Kennedy NA, Conley TE, et al · · 2021 · cited 31× · PMID 33545083 · DOI 10.1016/s2468-1253(21)00016-9
Practice pattern variability in the management of acute severe colitis: a UK provider survey.
Sebastian S, Lisle J, Subramanian S, Dhar A, et al · · 2020 · cited 6× · PMID 32587670 · DOI 10.1136/flgastro-2019-101277
Infliximab in acute severe colitis: getting the right dose.
Fiske J, Conley T, Sebastian S, Subramanian S. · · 2020 · cited 5× · PMID 33104078 · DOI 10.1136/flgastro-2020-101407

Verify or expand the search:

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Other Hull University Teaching Hospitals NHS Trust trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03907631 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hull University Teaching Hospitals NHS Trust
Last refreshed: 17 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03907631.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing