NCT03905200

Study on the Value of Three-dimensional Speckle Tracking Technique

Status unknown Last updated 5 April 2019

What this trial tests

trial testing 3D-speckle tracking imaging in Echocardiography, Three-Dimensional in 800 participants. Status unknown.

Timeline

1 March 2019

Primary endpoint
31 May 2020

31 December 2020

Quick facts

Lead sponsor	Beijing Hospital
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	800
Start date	1 March 2019
Primary completion	31 May 2020
Estimated completion	31 December 2020
Sites	1 location across China

Drugs / interventions tested

• 3D-speckle tracking imaging

Conditions studied

• Echocardiography, Three-Dimensional — all drugs for Echocardiography, Three-Dimensional →
• Coronary Artery Disease — all drugs for Coronary Artery Disease →

Sponsor

Beijing Hospital

Who can join

18 and older, any sex, with Echocardiography, Three-Dimensional or Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

For a long time, it has been hoped that doctors could screen and diagnosis of coronary heart disease through non-invasive imaging techniques, so as to maximize the benefit/risk ratio of patients. This trial is to explore the screening and diagnostic value of three-dimensional speckle tracking technology for coronary heart disease, and the evaluation value of 3D speckle track image(3D-STI) technology for cardiac function improvement after coronary intervention, and to seek reliable, accurate and quantifiable non-invasive imaging examination for the diagnosis, follow-up and prognosis of coronary heart disease.

In this study, coronary angiography is taken as the "gold standard", and 3d-STI echocardiography technology is proposed to combine with clinical characteristics of subjects for joint diagnosis, so as to evaluate the value of 3d-sti technology in the diagnosis of coronary heart disease.

Patients were followed up with echocardiography after interventional treatment to explore the feasibility of 3D-STI technology in evaluating cardiac function improvement.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Ensemble machine learning approach for screening of coronary heart disease based on echocardiography and risk factors.
   Zhang J, Zhu H, Chen Y, Yang C, et al · · 2021 · cited 15× · PMID 34116660 · DOI 10.1186/s12911-021-01535-5
2. Machine learning-enhanced echocardiography for screening coronary artery disease.
   Guo Y, Xia C, Zhong Y, Wei Y, et al · · 2023 · cited 9× · PMID 37170232 · DOI 10.1186/s12938-023-01106-x
3. Regional Myocardial Work Measured by Echocardiography for the Detection of Myocardial Ischemic Segments: A Comparative Study With Invasive Fractional Flow Reserve.
   Guo Y, Yang C, Wang X, Pei Z, et al · · 2022 · cited 9× · PMID 35369304 · DOI 10.3389/fcvm.2022.813710
4. Noninvasive assessment of myocardial work during left ventricular isovolumic relaxation in patients with diastolic dysfunction.
   Guo Y, Wang X, Yang CG, Meng XY, et al · · 2023 · cited 2× · PMID 36899310 · DOI 10.1186/s12872-023-03156-4
5. Echocardiographic video-driven multi-task learning model for coronary artery disease diagnosis and severity grading.
   Guo Y, Cai YH, Xu T, Song XY, et al · · 2025 · cited 1× · PMID 40787200 · DOI 10.3389/fbioe.2025.1556748
6. Two-Dimensional Speckle Tracking Echocardiography Identifies Coronary Artery Disease in 690 Patients: A Retrospective Study from a Single Center.
   Zhu H, Yang C, Li Y, Guo Y, et al · · 2021 · cited 1× · PMID 33561114 · DOI 10.12659/msm.929476