NCT03903133 is a Phase 4 clinical trial of Vitamin E in Sickle Cell Disease, sponsored by Ain Shams University.

Who is sponsoring NCT03903133?

NCT03903133 is sponsored by Ain Shams University.

What drugs are being tested in NCT03903133?

Interventions in NCT03903133: Vitamin E.

What condition does NCT03903133 study?

NCT03903133 studies Sickle Cell Disease.

Is NCT03903133 still recruiting?

NCT03903133 is currently completed. Last updated 3 May 2023.

Last reviewed 2023-05-03 · How we verify

NCT03903133

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle Patients

Completed Phase 4 Last updated 3 May 2023

What this trial tests

Phase 4 trial testing Vitamin E in Sickle Cell Disease in 50 participants. Completed in 1 May 2023.

Timeline

1 June 2016

Primary endpoint
1 May 2023

1 May 2023

Quick facts

Lead sponsor	Ain Shams University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	supportive care
Enrollment	50
Start date	1 June 2016
Primary completion	1 May 2023
Estimated completion	1 May 2023

Drugs / interventions tested

Vitamin E (VITAMIN E) — full drug profile →

Conditions studied

Sickle Cell Disease — all drugs for Sickle Cell Disease →

Sponsor

Ain Shams University

Who can join

Adults 2 to 18, any sex, with Sickle Cell Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study objectives to assess the role of endothelial monocyte-activating polypeptide II (EMAP II) as a marker of endothelial dysfunction and disturbed angiogenesis in sickle cell disease and to identify its correlation With the oxidative status.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy.
Vona R, Sposi NM, Mattia L, Gambardella L, et al · · 2021 · cited 65× · PMID 33669171 · DOI 10.3390/antiox10020296

Verify or expand the search:

Other trials of Vitamin E

Trials testing the same drug.

NCT07331103 — RESOLving INflammation Through Diet for Health (RESOLVIN) · NA · recruiting
NCT06081257 — The Effect of "KB-120" Small Molecular Nutrient in Women With Decreased Ovarian Reserve · NA · unknown
NCT05616442 — Ketotifen in Non-Alcoholic Fatty Liver Disease Patients · Phase 4 · completed
NCT06211478 — Role of Vitamin E in Gaucher Disease Patients · Phase 3 · completed
NCT04801849 — Vitamin E Dosing Study · Phase 2 · completed

Other recruiting trials for Sickle Cell Disease

Currently open trials in the same condition.

NCT07369024 — Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults · Phase 2 · recruiting
NCT06016634 — Alendronate for Osteonecrosis in Adults With Sickle Cell Disease · Phase 2 · recruiting
NCT06260891 — Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial · Phase 2 · recruiting
NCT07222475 — Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease · NA · recruiting
NCT07224360 — Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD) · Phase 2 · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03903133 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 3 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03903133.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing