NCT03901989 (TOP1) is a NA clinical trial of zeolite in Osteoporosis, sponsored by Polyclinic K-center.

Who is sponsoring NCT03901989?

NCT03901989 is sponsored by Polyclinic K-center.

What drugs are being tested in NCT03901989?

Interventions in NCT03901989: zeolite, cellulose.

What condition does NCT03901989 study?

NCT03901989 studies Osteoporosis.

Is NCT03901989 still recruiting?

NCT03901989 is currently completed. Last updated 3 April 2019.

Last reviewed 2019-04-03 · How we verify

NCT03901989: TOP1

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Osteoporosis - TOP1 Clinical Study

Completed NA Last updated 3 April 2019

What this trial tests

NA trial testing zeolite in Osteoporosis in 100 participants. Completed in 20 March 2017.

Timeline

14 January 2015

Primary endpoint
20 March 2017

20 March 2017

Quick facts

Lead sponsor	Polyclinic K-center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	100
Start date	14 January 2015
Primary completion	20 March 2017
Estimated completion	20 March 2017

Drugs / interventions tested

zeolite
cellulose — full drug profile →

Conditions studied

Osteoporosis — all drugs for Osteoporosis →

Sponsor

Polyclinic K-center

Who can join

Adults 40 to 80, any sex, with Osteoporosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study investigates the effect of zeolite on bone mineral metabolism. The clinical parameters include bone mineral density, bone remodelling markers, fractures and fallings, the subjective evaluation of the overall health status and intensity of the musculoskeletal pain measured by VAS.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial.
Kraljević Pavelić S, Micek V, Bobinac D, Bazdulj E, et al · · 2021 · cited 13× · PMID 33183068 · DOI 10.1177/1535370220968752
Zeolite-based nanoparticles drug delivery systems in modern pharmaceutical research and environmental remediation.
Pandya T, Patel S, Kulkarni M, Singh YR, et al · · 2024 · cited 12× · PMID 39262951 · DOI 10.1016/j.heliyon.2024.e36417
Clinical Evaluation of a Defined Zeolite-Clinoptilolite Supplementation Effect on the Selected Blood Parameters of Patients.
Kraljević Pavelić S, Saftić Martinović L, Simović Medica J, Žuvić M, et al · · 2022 · cited 9× · PMID 35712111 · DOI 10.3389/fmed.2022.851782
Clinical Parameters in Osteoporosis Patients Supplemented With PMA-Zeolite at the End of 5-Year Double-Blinded Clinical Trial.
Kraljević Pavelić S, Krpan D, Žuvić M, Eisenwagen S, et al · · 2022 · cited 4× · PMID 35833103 · DOI 10.3389/fmed.2022.870962
Translational Nanomedicine for Osteoporosis: Bridging Bone Signaling Networks and Targeted Delivery Systems.
Liu J, Shi S, Huang H, Wang C, et al · · 2026 · PMID 42023083 · DOI 10.2147/ijn.s580230

Verify or expand the search:

Other recruiting trials for Osteoporosis

Currently open trials in the same condition.

NCT07027306 — The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fract · recruiting
NCT07367776 — Patient Education in Osteoporosis (RCT-PATOS) · NA · recruiting
NCT06731608 — OsteoPorotic fracTure preventION System (OPTIONS) Research Study · NA · recruiting
NCT07281586 — Step-down Therapy After Long-term Osteoporosis Treatment · Phase 4 · recruiting
NCT07083557 — Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiome · recruiting

Other Polyclinic K-center trials

Trials by the same sponsor.

NCT05178719 — Treatment of Osteoporosis - TOP 2-5 Clinical Studies (Pear Control) · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03901989 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Polyclinic K-center
Last refreshed: 3 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03901989.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing