Who is sponsoring NCT03901261?

NCT03901261 is sponsored by Institut Jerome Lejeune.

What drugs are being tested in NCT03901261?

Interventions in NCT03901261: Neuro-imaging, Lumbar puncture.

What condition does NCT03901261 study?

NCT03901261 studies Down Syndrome, Alzheimer Disease.

Is NCT03901261 still recruiting?

NCT03901261 is currently status unknown. Last updated 8 February 2023.

Last reviewed 2023-02-08 · How we verify

NCT03901261

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer's Disease (TriAL21)

Status unknown NA Last updated 8 February 2023

What this trial tests

NA trial testing Neuro-imaging, Lumbar puncture in Down Syndrome in 200 participants. Status unknown.

Timeline

26 April 2019

Primary endpoint
31 March 2023

31 March 2023

Quick facts

Lead sponsor	Institut Jerome Lejeune
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	200
Start date	26 April 2019
Primary completion	31 March 2023
Estimated completion	31 March 2023
Sites	1 location across France

Drugs / interventions tested

Neuro-imaging, Lumbar puncture

Conditions studied

Down Syndrome — all drugs for Down Syndrome →
Alzheimer Disease — all drugs for Alzheimer Disease →

Sponsor

Institut Jerome Lejeune — full company profile →

Who can join

35 and older, any sex, with Down Syndrome or Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

TriAL21 study is an interventional, open, one arm, prospective, national and single center study. A total of 200 patients with Down syndrome, aged 35 years and over, without diagnosis of Alzheimer's disease will be enrolled into the study. Participating centre is Institut Jérôme Lejeune; outpatient's clinic dedicated to treating patients with cognitive deficiencies of genetic origin including patients with Down syndrome.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A review of the mechanisms underlying selected comorbidities in Alzheimer's disease.
Maciejewska K, Czarnecka K, Szymański P. · · 2021 · cited 45× · PMID 34121170 · DOI 10.1007/s43440-021-00293-5

Verify or expand the search:

Other recruiting trials for Down Syndrome

Currently open trials in the same condition.

NCT07416201 — Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy · recruiting
NCT07484464 — Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down Syndrome · NA · recruiting
NCT07428863 — Effects of Jump Rope on Navicular Drop in Down Syndrome · NA · recruiting
NCT07260136 — Cervical Spine Abnormalities in Down Syndrome · active not recruiting
NCT07248449 — Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises · NA · recruiting

Other Institut Jerome Lejeune trials

Trials by the same sponsor.

NCT05767216 — Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome · NA · recruiting
NCT05767203 — Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin · NA · recruiting
NCT03903666 — Anomalies of Nocturnal Gaz Exchanges in Patients With Down Syndrome · NA · completed
NCT03210675 — Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome · NA · unknown
NCT01576705 — Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syn · Phase 3 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03901261 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Institut Jerome Lejeune
Last refreshed: 8 February 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03901261.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing