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NCT03900832: EPR
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
EARLY_PHASE1 trial testing Without Heating in PAD in 33 participants. Completed in 31 July 2025.
31 July 2025
Quick facts
| Lead sponsor | Milton S. Hershey Medical Center |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 33 |
| Start date | 15 May 2019 |
| Primary completion | 31 July 2025 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Without Heating
- Warm Bath
- Neutral Bath
- Heating Suit
- Lower limb warm water immersion
- Gardner walking protocol
Conditions studied
- PAD — all drugs for PAD →
Sponsor
Milton S. Hershey Medical Center
Who can join
Adults 21 to 85, any sex, with PAD. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study objectives of this projects are to examine the hypothesis that the sympathetic and blood pressure responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease, via altering the sensitivity of the muscle afferent receptors.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03900832
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for PAD
Currently open trials in the same condition.
- NCT07130526 — Distrupt Stiffness Trial · NA · recruiting
- NCT05345431 — Endovascular Denervation for the Treatment of Patients With Peripheral Arterial Disease · NA · recruiting
- NCT04788914 — lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent ± Probiotics in CKD Patients With PAD · NA · recruiting
Other Milton S. Hershey Medical Center trials
Trials by the same sponsor.
- NCT05180552 — The HEALiX: Comparing the Efficacy of the HEALiX Device With Wrist Restraints in a Critical Care Setting · NA · withdrawn
- NCT07461844 — Transdiagnostic Sleep and Circadian Treatment for Autistic Adults · NA · not yet recruiting
- NCT06253858 — Ultrasound (US) Guided External Ventricular Catheter Placement · NA · not yet recruiting
- NCT07225699 — IN PATIENTS WITH CORNEAL ABRASIONS TREATED WITH COLLAGEN CORNEAL SHIELDS IN THE EMERGENCY DEPARTMENT SETTING · NA · not yet recruiting
- NCT07461168 — Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the Emergency Department · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03900832 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Milton S. Hershey Medical Center
- Last refreshed: 16 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03900832.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing