NCT03899870

Factors Predicting Recurrence in Rectal Cancer After Surgery

Completed Last updated 2 April 2019

What this trial tests

trial testing Rectal resection in Rectal Cancer in 188 participants. Completed in 15 January 2019.

Timeline

1 January 2000

Primary endpoint
31 December 2015

15 January 2019

Quick facts

Lead sponsor	ammar houssem
Status	Completed
Study type	OBSERVATIONAL
Enrollment	188
Start date	1 January 2000
Primary completion	31 December 2015
Estimated completion	15 January 2019

Drugs / interventions tested

• Rectal resection
• Neoadjuvant therapy — full drug profile →
• Adjuvant therapy — full drug profile →

Conditions studied

• Rectal Cancer — all drugs for Rectal Cancer →
• Rectal Adenocarcinoma — all drugs for Rectal Adenocarcinoma →

Sponsor

ammar houssem

Who can join

Eligibility, any sex, with Rectal Cancer or Rectal Adenocarcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Colorectal cancer is one of the most frequently diagnosed cancers and a major cause of cancer deaths worldwide. Recurrence after curative surgery is one of the major factors affecting the long-term survival and its frequency is estimated to be 22.5% at 5 years. of which 12% have local recurrence. The overall survival in case of recurrence of 11% at 5 years.

Several patient-, tumor-related and treatment-related prognostic factors have been found to be associated with the risk of recurrence of rectal adenocarcinoma. Some of these factors such as TNM stage, lymphatic and perineural invasion and vascular emboli have been found to affect recurrence free survival in most studies. While the impact of other factors such as distal resection margin, tumor size, extra capsular spread and neoadjuvant chemoradiotherapy on recurrence remains controversial. Moreover, most of the previous studies on prognostic factors have been from American and European countries with very little data from African countries. Recognition of these factors helps in identification of high-risk patients who require close and more rigorous postoperative surveillance. Hence this study was conducted to determine the factors affecting recurrence after curative resection of rectal cancer in African population.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Factors predicting recurrence after curative resection for rectal cancer: a 16-year study.
   Farhat W, Azzaza M, Mizouni A, Ammar H, et al · · 2019 · cited 22× · PMID 31660992 · DOI 10.1186/s12957-019-1718-1