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NCT03898622: TSHrenal
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
Phase 3 trial testing Levothyroxine in Chronic Kidney Diseases in 32 participants. Completed in 1 March 2019.
31 January 2019
Quick facts
| Lead sponsor | Hospital Civil de Guadalajara |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 1 October 2018 |
| Primary completion | 31 January 2019 |
| Estimated completion | 1 March 2019 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
- Levothyroxine (levothyroxine) — full drug profile →
Conditions studied
- Chronic Kidney Diseases — all drugs for Chronic Kidney Diseases →
- Subclinical Hypothyroidism — all drugs for Subclinical Hypothyroidism →
Sponsor
Hospital Civil de Guadalajara
Who can join
18 and older, any sex, with Chronic Kidney Diseases or Subclinical Hypothyroidism. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Study design: Phase II study, randomized, double-blind, unicentric, two-arm, placebo-controlled clinical trial. Methods and participants: Patients with Chronic Kidney Disease G2-G5 with proteinuria without renal replacement therapy, who come to the clinic of renal health clinic of the Fray Antonio Alcalde civil hospital. As criteria for non-inclusion, need for dialysis, primary hypothyroidism or pre-existing thyroid disease, ischemic heart disease in a period less than 6 months, arrhythmia, pregnancy, use of drugs that interact with synthesis of thyroid hormones, do not accept informed consent, thyroid stimulating hormone (TSH) \<2.5 uiml / L or TSH\> 10 uiml / L.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Pilot Trial on the Effect of Levothyroxine on Proteinuria in Patients With Advanced CKD.
Blackaller GN, Chávez-Iñiguez JS, Carreón-Bautista EE, González-Torres FJ, et al · · 2021 · cited 11× · PMID 33426390 · DOI 10.1016/j.ekir.2020.10.016
Verify or expand the search:
- PubMed search for NCT03898622
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Levothyroxine
Trials testing the same drug.
- NCT06731764 — Novel Approaches to the Treatment of Hypothyroidism · Phase 2, PHASE3 · recruiting
- NCT06625814 — A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028) · Phase 1 · completed
- NCT06428097 — Levothyroxine Supplementation for Heart Transplant Recipients · Phase 1 · recruiting
- NCT05712421 — A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in P · Phase 2 · completed
- NCT05412979 — A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Pati · Phase 2 · completed
Other recruiting trials for Chronic Kidney Diseases
Currently open trials in the same condition.
- NCT06593392 — Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus · Phase 2 · recruiting
- NCT07358572 — Eye-Brain-Kidney in CKD · recruiting
- NCT06463483 — Automated Insulin Delivery in Adults With Advanced Kidney Disease · NA · recruiting
- NCT06927024 — Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD) · NA · recruiting
- NCT07115953 — Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension · NA · recruiting
Other Hospital Civil de Guadalajara trials
Trials by the same sponsor.
- NCT07404345 — Low-Dose Apixaban Added to Standard Heparin Lock Versus Heparin Lock Alone to Prevent Tunneled Hemodialysis Catheters Dy · Phase 4 · not yet recruiting
- NCT07436130 — Curcumin in Critically Ill Patients With Sepsis · NA · not yet recruiting
- NCT07224997 — Trimethoprim-Sulfamethoxazole (TMP/SMX) Prophylaxis After Acute Kidney Injury to Prevent Post-discharge Infections · Phase 2 · not yet recruiting
- NCT07205627 — Evaluation of the Diaphragmatic Index Before and After a Pulmonary Rehabilitation Program in Patients With Interstitial · NA · not yet recruiting
- NCT07198750 — "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis" · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03898622 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Civil de Guadalajara
- Last refreshed: 2 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03898622.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing