NCT03893864: CoQ10Sport

Bioavailability and Impact of Coenzyme Q10 in Stressing Exercise in Senescence Athletes

Completed Phase 1 Last updated 28 March 2019

What this trial tests

Phase 1 trial testing Administration of a product with Fitosomed Ubiquinone in Coenzyme Q10 in 22 participants. Completed in 28 February 2019.

Timeline

1 March 2018

Primary endpoint
30 May 2018

28 February 2019

Quick facts

Lead sponsor	Centre d'Alt Rendiment
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	basic science
Enrollment	22
Start date	1 March 2018
Primary completion	30 May 2018
Estimated completion	28 February 2019
Sites	1 location across Spain

Drugs / interventions tested

• Administration of a product with Fitosomed Ubiquinone
• Coenzyme Q10 level in muscle biopsies
• Coenzyme Q10 level in plasma, blood cells, urine cells
• Total antioxidant capacity after strenous exercise

Conditions studied

• Coenzyme Q10 — all drugs for Coenzyme Q10 →
• Oxidative Stress — all drugs for Oxidative Stress →
• Aging — all drugs for Aging →

Sponsor

Centre d'Alt Rendiment

Who can join

Adults 50 to 65, any sex, with Coenzyme Q10 or Oxidative Stress. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

It is proposed to establish a group of subjects composed of 10 healthy individuals of\> 50 years and \<65, physically active, without metabolic or inflammatory pathology. All of them will undergo a health examination and the physical condition and the absence of contraindication of the sports practice will be characterized through a monitored effort test. Each subject will take a capsule of coenzyme Q10® INDENA for 30 days. The dose to be administered is 100 mg/d of CoQ10 a with food (noon). The state of physical condition and the biochemical and biological variables that reflect oxidative stress and mitochondrial functioning before and after the intervention will be measured.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Coenzyme Q₁₀ Treatment Monitoring in Different Human Biological Samples.
   Paredes-Fuentes AJ, Montero R, Codina A, Jou C, et al · · 2020 · cited 15× · PMID 33066002 · DOI 10.3390/antiox9100979
2. Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence.
   Tang W, Wang K, Feng Y, Tsui KH, et al · · 2025 · cited 8× · PMID 40110109 · DOI 10.1093/lifemedi/lnaf004