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NCT03892941: ELEPHANT
Electric Pace-pitched Hearing Achieves Natural Tonotopy
NA trial testing Imaged based fitting in Deafness in 30 participants. Status unknown.
18 March 2021
Quick facts
| Lead sponsor | Maastricht University Medical Center |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 18 March 2019 |
| Primary completion | 18 March 2021 |
| Estimated completion | 18 March 2021 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Imaged based fitting
Conditions studied
- Deafness — all drugs for Deafness →
Sponsor
Maastricht University Medical Center
Who can join
18 and older, any sex, with Deafness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In search of the best possible outcome for the severe hearing impaired who have regained the ability to hear by means of a cochlear implant (CI), electrical stimulation and the information it carries should match as closely as possible to what the human brain naturally has evolved to cope with and learned to process instead of relying on plasticity to adapt to an induced mismatch. At the moment, however, CI's are fitted with a 'one size fits all' principle. This is known to cause a mismatch between the frequencies presented by the CI electrode array and the frequencies represented at the corresponding natural acoustic location in an individual cochlea. In this study it is hypothesized that an individual imaged based fitting that pursues natural hearing alignment and is implemented from the start of the rehabilitation process, will improve the individual outcomes of electric hearing. The natural fitting strategy is thought to give rise to a steeper learning curve, result in a better performance in challenging listening situations, improve sound quality, complement better with residual acoustic hearing in the contralateral ear and win the preference of CI-recipients.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Imaging-based frequency mapping for cochlear implants - Evaluated using a daily randomized controlled trial.
Lambriks L, van Hoof M, Debruyne J, Janssen M, et al · · 2023 · cited 9× · PMID 37123376 · DOI 10.3389/fnins.2023.1119933 -
Evaluating hearing performance with cochlear implants within the same patient using daily randomization and imaging-based fitting - The ELEPHANT study.
Lambriks LJG, van Hoof M, Debruyne JA, Janssen M, et al · · 2020 · cited 7× · PMID 32576247 · DOI 10.1186/s13063-020-04469-x -
Learning to hear again with alternating cochlear frequency allocations.
van Hoof M, Lambriks L, van der Heijden K, Debruyne J, et al · · 2025 · PMID 39747380 · DOI 10.1038/s41598-024-83047-6 -
Evaluating hearing performance with cochlear implants within the same patient using daily randomization and imaging based fitting - The ELEPHANT study
Lambriks L, Hoof MV, Debruyne J, Janssen M, et al · · 2020 · DOI 10.21203/rs.2.23377/v1
Verify or expand the search:
- PubMed search for NCT03892941
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Maastricht University Medical Center trials
Trials by the same sponsor.
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- NCT04598516 — Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30 · withdrawn
- NCT04597892 — Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast · withdrawn
- NCT07287358 — Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II · NA · not yet recruiting
- NCT07501780 — Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03892941 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Maastricht University Medical Center
- Last refreshed: 27 March 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03892941.
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